Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

Email(s): Email ID Not Available

DOI: Not Available

Address: Y. Prem Kumar*, K. Vinod Kumar, V. Sai Kishore
Department of Pharmaceutics, St. Ann’s College of Pharmacy, Chirala
*Corresponding Author

Published In:   Volume - 6,      Issue - 10,     Year - 2013


ABSTRACT:
These techniques were aimed to develop sustain release formulation of Diclofenac Niosomes in order to provide better therapeutic effect. Diclofenac Niosomes was prepared by different techniques. These are : Ether injection method (F1), Ethanol injection method (F2), Sonication method (F3), Thin film hydration (F4) and Reverse phase evaporation technique (F5) using 1:1:1 ratio of drug, cholesterol and surfactant (Tween 80). The formulations were optimized from the above methods with respect to vesicle shape, particle size, entrapment efficiency, drug content, compatibility studies and in-vitro drug release. The in-vitro release of the drug was consistent. The time course of drugs and their effects in the body are assessed through pharmacokinetics which was provided by mathematical basis. The data collected from the release were incorporated into release kinetic analyses which are Higuchi equation, Korsmeyer-Peppas equations and Hixson-Crowell model along with zero order kinetics and first-order kinetics. The best fit with higher correlation (R2 > 0.98) was found with the Korsmeyer-Peppas equation with the R2 value of 0.993The well spherical shaped Niosomes were obtained in all the methods. FT-IR Spectra shows the drug and excipients were compatible. The in-vitro release studies indicate that all the formulations exhibits retarded release for 24hrs.


Cite this article:
Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore. Preparation and Evaluation of Diclofenac Niosomes by Various Techniques. Research J. Pharm. and Tech. 6(10): October 2013; Page 1097-1101.


Recomonded Articles:

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

DOI: Not Available         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Bhagyashree Purohit, Naveen Gupta, Shailesh Jain

DOI: Not Available         Access: Open Access Read More

Author(s): YK Naidu, Raghunadha Reddy S, Koteswara Rao Divi, MP Kalyan Reddy, I Sarath Chandiran, KN Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Gupta Khemchand, Singhvi I., Ashawat M.S., Gupta Santosh Kumar

DOI: Not Available         Access: Open Access Read More

Author(s): Sahu Sudeep, Dey Tathagata, Khaidem Somila, Y Jyothi

DOI: Not Available         Access: Open Access Read More

Author(s): R.V Rele, J.M. Parab, V.V. Mhatre, C.B. Warkar

DOI: Not Available         Access: Open Access Read More

Author(s): 1Valli G., Vasanthi A., Vijayalakshmi R., Thanga Thirupathi A

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi Kumar, Jismon Jose, Mahin M.M., Rahul Raut, Shantesh Masurkar, Narayana Swamy V.B.

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Author(s): Annapurna Uppala, Naga Swapna V, Neelima Devi R, Glory Sheren G, Kishore Kumar B

DOI: 10.5958/0974-360X.2015.00230.9         Access: Open Access Read More

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): N. Madoria, M. Pathodiya, A. Tiwari

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags