Author(s): Srujana Kumari D., Balasubramaniam V., Velrajan G., Deepthi N., Sushma R

Email(s): devani.srujana@gmail.com

DOI: Not Available

Address: Srujana Kumari D.*, Balasubramaniam V., Velrajan G., Deepthi N., Sushma R.
Smt. Sarojini Ramulamma College of Pharmacy, Sheshadrinagar, .Mahabubnagar, Andhra Pradesh, India-509001
*Corresponding Author

Published In:   Volume - 6,      Issue - 1,     Year - 2013


ABSTRACT:
The present research work was an attempt to design a formulation of Bilayer floating tablets with Metformin HCl as sustained release layer and Glibenclamide as immediate release layer for the treatment of type II diabetes mellitus. The extended release was prepared by wet granulation method using HPMC K 100M as sustained release polymer and sodium bicarbonate as gas generating agent to reduce floating lag time. Immediate release layer were prepared by direct compression using sodium starch glycolate as super disintegrant. Gastro retentive floating drug delivery systems have been designed to increase its residence time in the stomach. The granules were evaluated for bulk density, tapped density, Compressibility index, and hausner’s ratio. The granules showed satisfactory flow properties. The tablets were subjected to weight variation test, hardness test, friability test, drug content test and swelling index .All the tablets were passed the tests. With the incorporation of a gas generating agent the floating lag time was 27 sec, and the duration of floating was >8hrs. The drug release from the prepared tablets was sufficiently sustained (more than 8hrs) .The release kinetics of the Bilayer floating tablet was evaluated using regression coefficient analysis. The formulated tablets shows a Zero order drug release and the mechanism is correlated well with Korsmeyer peppas mode with super case II transport mechanism. Stability studies did not show any changes in physical appearance, physicochemical properties, and drug release.


Cite this article:
Srujana Kumari D., Balasubramaniam V., Velrajan G., Deepthi N., Sushma R. Formulation and Evaluation of Bilayer Floating Tablets of Metformin Hydrochloride and Glibenclamide. Research J. Pharm. and Tech. 6(1): Jan. 2013; Page 105-111.


Recomonded Articles:

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Adithya Chandrashekar, Anuraag Muralidharan, Ananthamurthy Koteshwara, Angel Treasa Alex, V. M. Subrahmanyam

DOI: 10.5958/0974-360X.2019.00791.1         Access: Closed Access Read More

Author(s): AK Jain, Naveen Sharma, Amit Upadhyay, Ashish Dixit

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Author(s): Gupalli Laxmi Narasimha, Dappu Jairam, Akkenapally Krishna, Mohammed Rehan Qureshi

DOI: 10.5958/0974-360X.2015.00025.6         Access: Open Access Read More

Author(s): Karanje Abhijit Sampatrao, Kandale Jitendra Bhalchandra, Jadhav Ravindra, Patil Manohar

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

Author(s): Zain Mhanna, Wehad Ibrahim, Tamim Hammad

DOI: 10.5958/0974-360X.2016.00040.8         Access: Open Access Read More

Author(s): S. P. Wate, N. J. Duragkar, M. R. Tajne, S. S. Jadhav

DOI: Not Available         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Alai M.S., Shinkar D.M., Saudagar R.B.

DOI: 10.5958/0974-360X.2017.00646.1         Access: Open Access Read More

Author(s): Anuradha A. Ranpise, Shilpa P. Chaudhari, Atul A. Phatak, Pratiksha M. Kadam

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags