D. Benito Johnson, C.Senthil Kumar R. Rajesh, R. Venkatnarayanan, Mohammed Ansar VK
D. Benito Johnson*, C.Senthil Kumar R. Rajesh, R. Venkatnarayanan and Mohammed Ansar VK
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu.
Volume - 6,
Issue - 1,
Year - 2013
Hepatocyte are the functional cells of the liver and perform a wide range of metabolic, secretory and endocrine functions. Hepatotoxicity implies chemical-driven liver damage. The liver plays a major role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the organ. Other chemical agents, those used in laboratories and industries, natural chemicals and herbal remedies can also cause hepatotoxicity. Borreria hispida seed flavonoid-rich fraction possesses free radical scavenging and antioxidant activity both in vitro and in vivo Borreria hispida Linn has been in use in the Indian system of medicine. Various part of the plant are useful in the treatment of antifertility, appetite, Bleeding in child birth, body ache, Gum trouble, scabies and skin disease, Stomach compliance, Ulcers, hepatitis, Wounds, head ache and tooth ache. The hepatotoxicity is induced by the paracetamol overdose, and the methanolic extract of Borreria hispida shows a good reduction of hepatotoxicity.
Cite this article:
D. Benito Johnson, C.Senthil Kumar R. Rajesh, R. Venkatnarayanan, Mohammed Ansar VK. Hepatoprotective Activity of Borreria hispida on Paracetamol induced Liver Damage. Research J. Pharm. and Tech. 6(1): Jan. 2013; Page 61-65.