Biofilms: The Microbial Castle of Resistance

Hisham A. Abbas; Fathy M. Serry; Eman M. EL-Masry

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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Biofilms: The Microbial Castle of Resistance

Author(s): Hisham A. Abbas, Fathy M. Serry, Eman M. EL-Masry

Email(s): h_abdelmonem@yahoo.com

DOI: Not Available

Address: Hisham A. Abbas, Fathy M. Serry, Eman M. EL-Masry
Department of Microbiology and Immunology-Faculty of Pharmacy-Zagazig University- Zagazig- Egypt
*Corresponding Author

Published In: Volume - 6, Issue - 1, Year - 2013

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ABSTRACT:
Biofilms are highly resistant to antimicrobial agents. As a consequence, biofilm-based infections are recalcitrant and their treatment is very difficult. Many factors contribute to the biofilm resistance to antimicrobials. The mechanisms of resistance include delayed diffusion of antibiotics through the biofilm matrix, low oxygen and nutrient, reduced growth rates and metabolism. Other resistance mechanisms involved are biofilm-specific phenotypic variants, stress response activation, over expression of efflux pumps, formation of persisters and quorum sensing. Key words:

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Cite this article:
Hisham A. Abbas, Fathy M. Serry, Eman M. EL-Masry. Biofilms: The Microbial Castle of Resistance. Research J. Pharm. and Tech. 6(1): Jan. 2013; Page 01-03.

Cite(Electronic):
Hisham A. Abbas, Fathy M. Serry, Eman M. EL-Masry. Biofilms: The Microbial Castle of Resistance. Research J. Pharm. and Tech. 6(1): Jan. 2013; Page 01-03. Available on: https://rjptonline.org/AbstractView.aspx?PID=2013-6-1-1