Author(s): Satyajit S. Deshmukh, Aamer Quazi, Ashish Saraf

Email(s): satyajitdeshmukh212@gmail.com

DOI: Not Available

Address: Satyajit S. Deshmukh*, Aamer Quazi, Ashish Saraf
K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 9,     Year - 2012


ABSTRACT:
The demand for mouth dissolving tablet (MDT) has been growing during the last decade especially for elderly and children who have swallowing difficulties. Chlorpromazine HCl is a potent anti-emetic, act by blocking D2 receptors in the Chemoreceptor trigger zone (CTZ) and antagonize apomorphine induced vomiting. In the present work, fast dissolving tablets of Chlorpromazine HCl were prepared by direct compression method using novel co-processed superdisintegrants consisting of crospovidone and sodium starch glycolate in the different ratios (1:1, 1:2 and 1:3). The developed superdisintegrants were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be < 25°, Carr’s index in the range of 10-15% and Hausner’s ratio in the range of 1.11-1.14. Fast dissolving tablets of Chlorpromazine hydrochloride were prepared using the above co-processed superdisintegrants and physical mixtures of superdisintegrants evaluated for pre-compression and post-compression parameters. The drug-excipients interaction was checked and found negative through IR and DSC studies. Among all the formulations CP1 containing co-processed superdisintegrants of crospovidone and sodium starch glycolate in ratio 1:1 was found to be promising and has shown an in-vitro dispersion time of 19 sec, wetting time of 24 sec, almost complete release of drug within 8 minutes. Finally it was concluded that FDT of Chlorpromazine hydrochloride can be successfully formulated by direct compression method with improved patient compliance.


Cite this article:
Satyajit S. Deshmukh, Aamer Quazi, Ashish Saraf. Formulation and Evaluation of Fast Dissolving Tablets of Chlorpromazine Hydrochloride Using Novel Co-processed Superdisintegrants. Research J. Pharm. and Tech. 5(9): September 2012; Page 1235-1240.


Recomonded Articles:

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Priti Patel, Ashok Kumar P., Hemil Shah, Nikunj Patel, Pratik Kheni, Someshwara Rao B., Suresh V. Kulkarni, Babitha S.

DOI: Not Available         Access: Open Access Read More

Author(s): Mettu Srikanth Reddy, Mallikarjun Setty

DOI: Not Available         Access: Open Access Read More

Author(s): Deepali Avinash Meher

DOI: Not Available         Access: Open Access Read More

Author(s): Mahaveer Singh, Gautam Singhvi, SG Kaskhedikar, Love soni

DOI: Not Available         Access: Open Access Read More

Author(s): Siddharth Kumar Sahu, Ajazuddin, Tripti Banjare, Swapnil Gupta, Akansha Bhandarkar, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Palak Agrawal, Pooja Yadav, Aditi Bhatt, Kailash Sahu, Deeksha Dewangan, HemlataThapa, Deepika, GyaneshSahu, Mukesh Sharma, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0974-360X.2018.00209.3         Access: Open Access Read More

Author(s): A Pavan Kumar, J Satyanaryana, V Sai Kishore, TE Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Ramesh V Shinde, Pawar Jaydip B, Kadam Sagar D, Landge Dhananjay A, Rahul Ahirrao, Kulkarni Vaishali , Patil VG, Pawar Gitanjali R

DOI: Not Available         Access: Open Access Read More

Author(s): Ujwala R. Bagmar, Dinesh C. Sancheti, Sarika R. Zade, Varsha K. Pawar, Nanda R. Badhe

DOI: Not Available         Access: Open Access Read More

Author(s): Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain

DOI: Not Available         Access: Open Access Read More

Author(s): Shah Dhiren P, Jain Vineet C, Sonani Nitesh G, Dalvadi Hitesh P, Dhimmar Hiren D

DOI: Not Available         Access: Open Access Read More

Author(s): Valli G.1, Ramu K.1, Mareeswari P.1 and Thanga Thirupathi A2

DOI: Not Available         Access: Open Access Read More

Author(s): Monica RP Rao, Devidas G Bachhav, Ramdas B Rode, Komal R Nikam, Namrata D Pathade

DOI: Not Available         Access: Open Access Read More

Author(s): Satyabrata bhanja, K. Lakshmi Deepthi, Muvvala Sudhakar, Bibhuti Bhusan Panigrahi

DOI: Not Available         Access: Open Access Read More

Author(s): Srinivasa DS, Narayana Charyulu R, Satyanarayana DS, Srilakshmi D

DOI: 10.5958/0974-360X.2015.00249.8         Access: Open Access Read More

Author(s): K.B. Koteshwara, Anup Naha, Bishu Choubey

DOI: Not Available         Access: Open Access Read More

Author(s): Nitin Chandrakant Mohire, Adhikrao Vyankatrao Yadav, Vaishali Kondibhau Gaikwad

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags