Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Development and Validation of Spectrophotometric Method for Analysis of Ziprasidone HCl

Author(s): Arun Shirwaikar, Sarala Devi, K Premalatha, Muhammed Maqbool, Sreejith K.R.

Email(s): krsreejith_5228@yahoo.co.in

DOI: Not Available

Address: Arun Shirwaikar1, Sarala Devi2, K Premalatha3, Muhammed Maqbool3 and Sreejith K.R.3*
1College of Pharmacy, Gulf Medical University, Ajman, U A E
2Department of Medicine, Pariyaram Medical College, Kannur, India
3Academy of Pharmaceutical Science, Pariyaram Medical College, Kannur, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 9,     Year - 2012

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ABSTRACT:
A simple, precise and sensitive extractive Spectrophotometric method has been described for the assay of Ziprasidone HCl in pure and pharmaceutical preparations. This method is based on the formation of ion-pair complex between the basic nitrogen of the drug with bromothymol blue (BTB) in acidic buffer solution. The formed complex was extracted with chloroform and measured at 415 nm. Beer’s law was obeyed in the range 4-24 µg/ ml with correlation coefficient (n = 6) = 0.9999. The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job’s method. The proposed methods have been applied successfully for the analysis of Ziprasidone in pure and in its dosage forms. These developed methods were validated for accuracy and precision.


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Cite this article:
Arun Shirwaikar, Sarala Devi, K Premalatha, Muhammed Maqbool, Sreejith K.R. Development and Validation of Spectrophotometric Method for Analysis of Ziprasidone HCl. Research J. Pharm. and Tech. 5(9): September 2012; Page 1229-1234.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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