Author(s): R.B. Desi Reddy, G. Naga Sowjanya, V. Shanthi, P. Rizpah, G. Geetha, B.R. Maneesha

Email(s): naga.sowji@gmail.com

DOI: Not Available

Address: R.B. Desi Reddy, G. Naga Sowjanya, V. Shanthi, P. Rizpah, G. Geetha, B.R. Maneesha
Nalanda Institute of Pharmaceutical Sciences, Kantepudi, Sattenapalli.
*Corresponding Author

Published In:   Volume - 5,      Issue - 9,     Year - 2012


ABSTRACT:
Development of new analytical methods for the determination of drugs in pharmaceutical dosage forms is more important in pharmacokinetic, toxicological and biological studies. Ezetemibe is a hypo-lipidaemic agent. Two simple and sensitive spectrophotometric methods (Method A and Method B) were developed for the estimation of Ezetemibe in bulk and pharmaceutical preparations. The two methods are based on the formation of yellow chromophores with PDAB and Picric acid exhibiting maximum absorption at 420nm and 400nm respectively. These two methods obey Beer’s law in the concentration range of 10-50µg/ml and 10-30µg/ml respectively. The methods were validated for use in routine quality control studies of Ezetemibe. Interference studies were conducted and it was found that the common excipients usually present in dosage forms do not interfere in the proposed methods. The optical characteristics, regression analysis data and precision of the methods were calculated. The accuracy of the methods was evaluated by estimating the amount of Ezetemibe in previously analyzed samples to which known amounts of Ezetemibe were spiked. The accuracy of the methods was also confirmed by comparison of the results obtained by proposed and reference methods. The methods were validated for use in routine quality control of Ezetemibe in bulk and pharmaceutical preparations.


Cite this article:
R.B. Desi Reddy, G. Naga Sowjanya, V. Shanthi, P. Rizpah, G. Geetha, B.R. Maneesha. Estimation of Ezetemibe by Visible Spectrophotometry. Research J. Pharm. and Tech. 5(9): September 2012; Page 1223-1224.


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