Author(s): C. M. Jamkhandi, John Intru Disouza

Email(s): cmjamakhandi@gmail.com

DOI: Not Available

Address: C. M. Jamkhandi*, John Intru Disouza
Department of Pharmacy JJT University Jhunjhunu Rajasthan India
*Corresponding Author

Published In:   Volume - 5,      Issue - 9,     Year - 2012


ABSTRACT:
Five novel [(1H-benzotriazol-1-ylacetyl)amino]acetic acid derivatives were synthesized by substituting corresponding amino acids on a reaction intermediate 1H-benzotriazol-1-ylacetyl chloride. The derivatives were characterized by physical, chemical parameters, TLC and spectral data. Synthesized derivatives from Ib to Vb were screened for anti microbial activity against, S. Aureus, B. Subtilis, E. coli, S. typhi, C Albicanse, A Niger. MIC was measured against norfloxacine and ketoconazole. Present study confirms the synthesized derivatives endowed with effective anti-microbial activities.


Cite this article:
C. M. Jamkhandi, John Intru Disouza. Synthesis and Antimicrobial Evaluation of [(1H-benzotriazol-1-ylacetyl) amino] Acetic Acid Derivatives. Research J. Pharm. and Tech. 5(9): September 2012; Page 1197-1200.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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