Author(s): Yogendra Nayak, Jayashree B.S., Unnikrishnan M.K.

Email(s): yogendranayak@gmail.com , yogendra.nayak@manipal.edu

DOI: Not Available

Address: Yogendra Nayak1*, Jayashree B.S.2, Unnikrishnan M.K.3
1Dept of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka – 576104, India
2Dept of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka – 576104, India
3Dept of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka – 576104, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 8,     Year - 2012


ABSTRACT:
Diabetes mellitus (DM) is a metabolic disorder associated with retinopathy, nephropathy, cardiomyopathy, peripheral neuropathy and autonomic neuropathies leading to gastrointestinal, genitourinary, cardiovascular complications and sexual dysfunction. The present available antidiabetic agents are not interferingin the modulation of these complications. Benzopyran-4-one is the basic moiety present in naturally occurring flavonoids. Number of flavonoids hasbeen found to be antidiabetic and many of themmodulate diabetes related complications by acting on newer targets. Hence, an attempt was made to review the possibilities of modulating benzopyran-4-one scaffold for lead optimization in antidiabetic drug discovery.


Cite this article:
Yogendra Nayak, Jayashree B.S., Unnikrishnan M.K. Benzopyran-4-one is an Ideal Pharmacophore for Lead Optimization in Antidiabetic Drug Discovery. Research J. Pharm. and Tech. 5(8): August 2012; Page 1025-1033.


Recomonded Articles:

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Santhosh Kumar V, Praveen D

DOI: 10.5958/0974-360X.2016.00123.2         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Vaddi Mounika, S. Sarumathy, J. Anisha Ebens, T. S. Shanmugarajan

DOI: 10.5958/0974-360X.2017.00003.8         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags