Author(s): U. Viplava Prasad, Manukonda Syam Bab, Buridi Kalyana Ramu

Email(s): msyambab@gmail.com , kalyanaramu23566@gmail.com

DOI: Not Available

Address: U. Viplava Prasad1, Manukonda Syam Bab1*, Buridi Kalyana Ramu2
1Department of Organic Chemistryand Analysis of Foods Drugs andWater Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003 Andhra Pradesh (India)
2Department of Chemistry, Maharajah’s College (Aidedand Autonomous), Vizianagaram-535002 (AP) India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 8,     Year - 2012


ABSTRACT:
Three simple and sensitive extractive visible spectrophotometric methods (A, B and C) for the assay of almotriptan malate in pure and dosage forms based on the formation of colored chloroform soluble ion - association associates under specified experimental conditions are described. Three dyes namely acidic dye orange dye II (TPOOO, method A) or Naphthalene blue 12 BR (NB12BR, method B) or bromo cresol purple (BCP, method C) are utilized. The extracts of the ion-associates exhibit absorption maxima at 480nm, 620nm and 410nm for methods A, B and C respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (2.0 -10) µg/ml for method A, (4.0-12) µg/ml for method B, (8.0 -24) µg/ml for method C respectively. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the almotriptan malate in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.


Cite this article:
U. Viplava Prasad, Manukonda Syam Bab, Buridi Kalyana Ramu. Visible Spectrophotometric Assay of Almotriptan Malate using Ion-association Methods. Research J. Pharm. and Tech. 5(8): August 2012; Page 1107-1111.


Recomonded Articles:

Author(s): Hemlata M. Nimje, Rajesh J. Oswal, Sandip S. Kshirsagar, Manoj Chavan

DOI: Not Available         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): Pratik N. Shah, Bhavini N. Patel, Chaganbhai N. Patel

DOI: Not Available         Access: Open Access Read More

Author(s): Kumaraswamy G., J.M. Rajendrakumar, J.V.L.N. Sheshagirirao, U. Ashok Kumar, M. Arunadevi

DOI: Not Available         Access: Open Access Read More

Author(s): Bulusu Ravi Teja, Bhupathi Raju Kishan Varma, Chandaka Prasanna Kumar, Mukthinuthalapati Mathrusri Annapurna

DOI: 10.5958/0974-360X.2017.00206.2         Access: Open Access Read More

Author(s): B Srivastava, Uttam Singh Baghel, Pradeep Swarnkar and Shuchi Dave

DOI: Not Available         Access: Open Access Read More

Author(s): Anuruddha R. Chabukswar, Shital D. Tambe, Vishnu P. Choudhari, Shailesh N. Sharma, Mayuri N. Mohokar, Subhash Chate

DOI: Not Available         Access: Open Access Read More

Author(s): Garima Singh, Amrita Mishra, Anurag Verma, Arun K. Mishra

DOI: Not Available         Access: Open Access Read More

Author(s): Lakshmi Aswini G., Dhachinamoorthi D., Seshagiri Rao J.V.L.N., Prasada Rao C.H., Surekha M.L

DOI: Not Available         Access: Open Access Read More

Author(s): Venugopal Darak, Arvind B. Karadi, Md. Arshad, S. Appal Raju

DOI: Not Available         Access: Open Access Read More

Author(s): N. Tamilselvi, Tejaswi Bhavanam, Tessy Susan Thomas, Dona Sara Kurian, K. Sruthi, Manasvi Sunkara, M.R. Deepthi

DOI: Not Available         Access: Open Access Read More

Author(s): Ugye J.T., Uzairu A., Idris, S. O., Kwanashie H.O.

DOI: Not Available         Access: Open Access Read More

Author(s): Prasada Rao CH , Seshagiri Rao JVLN, Dhachinamoorthi D, Lakshmi Aswini G, Ashok K

DOI: Not Available         Access: Open Access Read More

Author(s): V Niraimathi, V Prema , Ajithadas Aruna, A Jerad Suresh

DOI: Not Available         Access: Open Access Read More

Author(s): Arun Shirwaikar, Sarala Devi, K Premalatha, Muhammed Maqbool, Sreejith K.R.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags