Author(s): U. Viplava Prasad, Manukonda Syam Bab, Buridi Kalyana Ramu

Email(s): msyambab@gmail.com , kalyanaramu23566@gmail.com

DOI: Not Available

Address: U. Viplava Prasad1, Manukonda Syam Bab1*, Buridi Kalyana Ramu2
1Department of Organic Chemistryand Analysis of Foods Drugs andWater Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003 Andhra Pradesh (India)
2Department of Chemistry, Maharajah’s College (Aidedand Autonomous), Vizianagaram-535002 (AP) India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 8,     Year - 2012


ABSTRACT:
Three simple and sensitive extractive visible spectrophotometric methods (A, B and C) for the assay of almotriptan malate in pure and dosage forms based on the formation of colored chloroform soluble ion - association associates under specified experimental conditions are described. Three dyes namely acidic dye orange dye II (TPOOO, method A) or Naphthalene blue 12 BR (NB12BR, method B) or bromo cresol purple (BCP, method C) are utilized. The extracts of the ion-associates exhibit absorption maxima at 480nm, 620nm and 410nm for methods A, B and C respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (2.0 -10) µg/ml for method A, (4.0-12) µg/ml for method B, (8.0 -24) µg/ml for method C respectively. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the almotriptan malate in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.


Cite this article:
U. Viplava Prasad, Manukonda Syam Bab, Buridi Kalyana Ramu. Visible Spectrophotometric Assay of Almotriptan Malate using Ion-association Methods. Research J. Pharm. and Tech. 5(8): August 2012; Page 1107-1111.

Cite(Electronic):
U. Viplava Prasad, Manukonda Syam Bab, Buridi Kalyana Ramu. Visible Spectrophotometric Assay of Almotriptan Malate using Ion-association Methods. Research J. Pharm. and Tech. 5(8): August 2012; Page 1107-1111.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2012-5-8-13


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available