Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Formulation and Evaluation of Gastro-Retentive Drug Delivery System of Some Selected Drugs

Author(s): Patil NarayanVenkatrao, S. Appala Raju

Email(s): patilnarayanv@gmail.com

DOI: Not Available

Address: Patil NarayanVenkatrao*, S. Appala Raju.
Department of Pharmaceutical Analysis, HKES’s College of Pharmacy, Sedam Road, Gulbarga, Karnataka-585105, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 7,     Year - 2012

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ABSTRACT:
Itopride hydrochloride is a novel gastroprokinetic, widely absorbed from the stomach and upper part of the small intestine and absorption becomes less as the drug passes beyond this. The bioavailability can be improved by making the drug completely absorbed in the stomach and upper part of the small intestine. It has a half life of 5h2. The short half life of Itopride hydrochloride necessitates frequent administration. Therefore it is highly desirable to have a controlled release dosage form for Itopride hydrochloride. The objective of this present investigation was to formulate gastro-retentive tablets of itopride hydrochloride using a gas generating agent. We attempted to formulate to retain the matrix tablet in the stomach and subsequently to provide delivery of the drug over the period of time of GRT.


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Cite this article:
Patil NarayanVenkatrao, S. Appala Raju. Formulation and Evaluation of Gastro-Retentive Drug Delivery System of Some Selected Drugs. Research J. Pharm. and Tech. 5(7): July 2012; Page 942-945.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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