Author(s): Shiv Kumar Patel, Moumita Sinha, Mitashree Mitra

Email(s): shivpatel.anthro@gmail.com

DOI: Not Available

Address: Shiv Kumar Patel*, Moumita Sinha, Mitashree Mitra
School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur-492010 (C.G.)
*Corresponding Author

Published In:   Volume - 5,      Issue - 7,     Year - 2012


ABSTRACT:
Tobacco is an established risk factor for oral cancer. Polymorphism of a great number of phase I and phase II XME genes have been widely elucidated over the last three decades, may play a role in determining an individual’s susceptibility to oral cancer in particular and in combination with specific environmental exposure such as smoking. Glutathione S-transferases (GSTM1 and GSTT1) involved in detoxify tobacco smoke constituents and polymorphisms within GSTM1 and GSTT1 genes can result in a complete lack of enzyme activity. In this hospital based case-control study, 104 oral cancer patients (cases) and 104 controls were studied to determine the risk of the disease due to polymorphisms at GSTM1 and GSTT1 loci. Overall, we observed no statistically significant associations between the polymorphisms and oral cancer genotypes on GSTT1 locus, but the simultaneous presence of two mutant genotypes, one of each of two loci (GSTM1 and GSTT1) increased about four fold risk of oral cancer (OR= 3.79, 95% CI- 0.32-3.54). In conclusion, our preliminary results are consistent with earlier published study supporting associations between oral cancer and GSTM1 and GSTT1 homozygous null genotypes.


Cite this article:
Shiv Kumar Patel, Moumita Sinha, Mitashree Mitra. Glutathione-S-transferase M1 and T1 gene Polymorphism as Risk Factors of Oral Squamous Cell Carcinoma: A Preliminary Investigation. Research J. Pharm. and Tech. 5(7): July 2012; Page 918-920.


Recomonded Articles:

Author(s): Pradeep Kumar Samal, Shani Sharaf, N.R. Beck, J.S. Dangi

DOI: Not Available         Access: Open Access Read More

Author(s): Chinedu Fredrick Anowi, Nnabuife Chinedu Cardinal, A.F. Onyegbule, L.N. Anowi

DOI: Not Available         Access: Open Access Read More

Author(s): Saurabh Bharadwaj, U.V.S. Teotia, Kishan Singh, Rajib Sharma, Yogendra Singh

DOI: Not Available         Access: Open Access Read More

Author(s): Pradeep Kumar Samal*, Shani Sharaf, N.R. Beck and J.S. Dangi

DOI: Not Available         Access: Open Access Read More

Author(s): Roushan Mubarak, Shaden Haddad, Outhman Hamdan

DOI: 10.5958/0974-360X.2016.00022.6         Access: Open Access Read More

Author(s): G. Bhuvaneshwari, . A. S. Shameembanu, M. Kalyani

DOI: 10.5958/0974-360X.2018.00244.5         Access: Open Access Read More

Author(s): Nadheema Hammood Hussein, Baydaa Hussein Alwan, Buthainah Mohammed Taha, Sinaa Mahdi Shakir, Ban Mahdi Shakir

DOI: 10.5958/0974-360X.2019.00676.0         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags