Author(s): Pankaj Arora, M. S. Ranawat, Namita Arora

Email(s): pankaj_arora1111@yahoo.com

DOI: Not Available

Address: Pankaj Arora1*, M. S. Ranawat2, Namita Arora3
1Department of Pharmaceutical Chemistry, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
2Department of Pharmaceutical Chemistry, B N College of Pharmacy, Udaipur, Rajasthan, India
3Department of Pharmacognosy, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 7,     Year - 2012


ABSTRACT:
Various Coumarin derivatives (1a-1f) were synthesized and evaluated for their antipsychotic action using Apomorphine induced behavior model, 5-HTP induced behavior model, Conditioned avoidance response model and Rota rod experiment. All compounds showed significant (P?0.05) antipsychotic activity during study and it was found that target compounds have affinity for dopamine as well as for 5-HT receptors. The compound 1d, N-(6- fluorobenzo [d]thiazol-2-yl)-2-(4-(2-(4-methyl-2-oxo-2H-chromen-7-yloxy) ethyl) piperazin-1-yl) acetamide has been found to have significant atypical behaviour.


Cite this article:
Pankaj Arora, M. S. Ranawat, Namita Arora. Synthesis and Screening of Some Novel Coumarin Derivatives for Antipsychotic Activity. Research J. Pharm. and Tech. 5(7): July 2012; Page 968-972.


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DOI: 10.5958/0974-360X 

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