Author(s): Kamepalli Sujana, D. Gowri Sankar, K. Abbulu

Email(s): sujana_36@yahoo.co.in

DOI: Not Available

Address: Kamepalli Sujana1*, D. Gowri Sankar2, K. Abbulu3
1Pharmaceutical Analysis Division, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur-522510, A.P, India
2Pharmaceutical Analysis Division, Andhra University, Visakhapatnam 3Department of Pharmaceutics, MRIPS, Hyderabad
*Corresponding Author

Published In:   Volume - 5,      Issue - 7,     Year - 2012


ABSTRACT:
This investigation describes a new precise, sensitive and accurate RP-HPLC method for the Simultaneous estimation of Donepezil and Memantine in Bulk and Tablets. The resolution of two drugs was achieved on Agilent C8 (150mm x 4.6mm i.d., 3.5mm particle size) column with UV detection at 230nm and the mobile phase consist of Buffer, water and Acetonitrile (50:5:45 v/v).Using chromatographic conditions described Donepezil and Memantine were well resolved with mean retention times of 3.707 and 6.976 min, respectively. Linear response (r>0.999) was observed over the range of 50-70µg/ml for Donepezil and 100-140µg/ml for Memantine. The lower limit of quantification and lower limit of detection was 9.95 and 3.0 for Donepezil and 10.01 and 3.14 for Memantine. The Validation parameters were performed according to the ICH guidelines and the proposed method can be useful in the routine analysis for the determination of Donepezil and Memantine in Pharmaceutical dosage forms.


Cite this article:
Kamepalli Sujana, D. Gowri Sankar, K. Abbulu. Simultaneous Estimation of Donepezil and Memantine by Reverse Phase HPLC in Bulk and Pharmaceutical Dosage Form. Research J. Pharm. and Tech. 5(7): July 2012; Page 958-961.


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DOI: 10.5958/0974-360X 

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