ABSTRACT:
Compounds containing 1,2,4-triazole moiety find wide range of applications and substituted 1,2,4-triazoles are becoming more prevalent in functional materials that are at the cutting edge of new technology. The biological activities of 1,2,4-triazole derivatives are well documented and important discoveries in this area are continued, though the electron donor and coordinating ability of 1,2,4-triazoles has also seen an increase in their use as ligands, functional polymers, and industrial coatings. 1,2,4-triazole has shown its importance as antimicrobial, anti-inflammatory, hypoglycemic, antidepressant, antitubercular, analgesic, antimalarial and anticancer agents. This article is based on different pharmacological activities exhibited by the various compounds containing mercapto and/or thione substituted 1,2,4-triazole heterocyclic ring systems. This review highlighted the basic pharmacophoric requirements for the successful development in the designing of novel antibacterial, antifungal, antitubercular, and anti-inflammatory mercapto triazole agents.