Author(s): Nilesh A. Bari, Shialesh N. Sharma, Yashwant T. Dangat, Swati C. Jagdale, Aniruddha R. Chabukswar, Bhanudas S. Kuchekar

Email(s): jagdaleswati@rediffmail.com

DOI: Not Available

Address: Nilesh A. Bari, Shialesh N. Sharma, Yashwant T. Dangat, Swati C. Jagdale*, Aniruddha R. Chabukswar, Bhanudas S. Kuchekar
MAEER'S Maharashtra Institute of Pharmacy, Sr. No. 124, MIT Campus, Paud Road, Kothrud, Pune-411038, MS
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2012


ABSTRACT:
The aim of the current study was the development of Esomeprazole buccal adhesive tablets using direct compression. Buccoadhesive tablets of Esomeprazole which were designed to prolong the buccal residence time after oral administration. Buccal adhesive formulations were developed using with various combinations of mucoadhesive polymers namely, Carbopol 934 P, HPMC K4M, sodium alginate. The prepared Esomeprazole tablets were evaluated for weight variation, thickness, hardness, surface PH, content uniformity and swelling index. In-vitro drug Permeation Studies by egg membrane, ex-vivo drug Permeation Studies by goat membrane. The effect of formulation composition on the release pattern was also investigated. Most formulations showed Esomeprazole controlled release profiles depended on the grade and polymer ratio. Tablets containing Carbopol 934 P and sodium alginate in the ratio of 1:1(B3) showed the maximum drug release of 94.16% in 8 hours. The swelling index was proportional to sodium alginate content and inversely proportional to Carbopol 934 P content. Formulation B3 showed maximum swelling index after 6 hours. The surface pH of all tablets was found close to neutral PH. The release mechanisms were found to fit Peppas’ kinetic model.


Cite this article:
A. Bari, Shialesh N. Sharma, Yashwant T. Dangat, Swati C. Jagdale, Aniruddha R. Chabukswar, Bhanudas S. Kuchekar. Controlled Release from Directly Compressible Esomeprazole Buccal Tablet. Research J. Pharm. and Tech. 5(5): May2012; Page 652-657.


REFERENCES:

1.       Bhanja1S, Ellaiah P, Martha SK, Sahu PK, Tiwari SP, Formulation and in vitro evaluation of mucoadhesive buccal tablets of Timolol maleate, Int J Pharm Biomed Res, 1(4); (2010):129-134.

2.       Boyapally H, Nukala RK, Bhujbal P, Douroumi D, Controlled release from directly compressible theophylline buccal tablets, Colloids and Surfaces B: Biointerfaces, 77;(2010):227-233.

3.       Chandira M, Mehul, Debjit, Chiranjib, Kumudhavalli, Formulation, Design and Development of Buccoadheshive Tablets of Verapamil Hydrochloride, International Journal of PharmTech Research, 1(4);2009:1663-1677.

4.       Alagusundaram M, Chengaiah B, Ramkanth S,  Angala Parameswari S, Formulation and Evaluation of Mucoadhesive Buccal Films of Ranitidine, International Journal of PharmTech Research, 1(3); 2009: 557-563.

5.       Jafar A, Ali Nokhodchi, Djavad F, Massoud A, Development and evaluation of buccoadhesive propranolol hydrochloride tablet formulations: effect of fillers, IL Farmaco, 59; (2004):155-161.

6.       Emami J, Varshosaz J, Saljoughian N, Development and evaluation of controlled-release Buccoadhesive verapamil hydrochloride tablets, DARU, 16(2); 2008:60-69.

7.       Sudhakar Y, Kuotsu K, Bandyopadhyay AK, Buccal bioadhesive drug delivery-A promising option for orally less efficient drugs, Journal of Controlled Release 114; (2006): 15-40.

8.       Nair AB, Gupta R, Kumria R, Jacob S; Formulation and Evaluation of Enteric Coated Tablets of Proton Pump Inhibitor, Jour of Basic and Clinical Pharmacy, 1(4); (2010):215-221.

9.       Basawaraj SP, Sandeep ST, Hariprasanna RC, Gururaj VW; Development and In-Vitro Evaluation of Mucoadhesive Buccal Tablets of Tizanidine Hydrochloride using Natural Polymer Xanthan Gum, International Journal of Pharmaceutical Science Review and Research, 8(2);(2011): 140-146.

10.     Rajesh Khanna, SP Agarwal, Alka Ahuja; preparation and evaluations of bioerodiable buccal tablet containing clotriamazole, Inter Jour of Pharmaceutics, 138; (1996): 67-73.

11.     Manivannan R, Balasubramaniam A, Prem Anand DC, Sandeep G; Formulation and In -vitro evaluation of mucoadhesive buccal tablets of Diltiazem Hydrochloride, Research Journal of  Pharm. and Tech., 1(4);(2008):478-480.

12.     Spiegeleer BD, Vooren LV, Voorspoels J, Thoné D, Dissolution stability and IVIVC investigation of a buccal tablet; Analytica Chimica Acta, 446; (2001): 345-351.

13.     Ankarao A, Babu rao CH ,Devanna N, Formulation and Evaluation of Buccoadhesive Bilayered Tablets of Metoprolol tartrate, International Journal of Research in Pharmaceutical and Biomedical Sciences, 1(2); (2010):67-71.

14.     Luana Perioli, Valeria Ambrogi, Daniela Rubini, Stefano Giovagnoli, Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease, Journal of Controlled Release, 95; (2004):521-533.

15.     Park CR, Munday DL, Development and evaluation of a biphasic buccal adhesive tablet for nicotine replacement therapy, International Journal of Pharmaceutics, 237; (2002):215-226.

16.     Ikinci G, Senel S, Wilson CG, Sumnua M, Development of a buccal bioadhesive nicotine tablet formulation for smoking cessation, International Journal of Pharmaceutics, 277; (2004):173-178.

17.     Choi HG , Jung JH , Yong CS , Rhee CD, Formulation and in vivo evaluation of omeprazole buccal adhesive tablet, Journal of Controlled Release 68;(2000) :405-412.

18.     Choi HG, Kima CK, Development of omeprazole buccal adhesive tablets with stability enhancement in human saliva, Journal of Controlled Release 68; (2000): 397-404.

19.     Nazila SM, Montakarn C, Johnston TP, The use of mucoadhesive polymers in buccal drug delivery, Advanced Drug Delivery Reviews, 57; (2005): 1666-1691.

20.     Buket T, Yilmaz, Olgun G, Sirri K, Design and evaluation of sustained-release and buccal adhesive propranolol hydrochloride tablets, Journal of Controlled Release, 38; (1996): 11-20.

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): Hitesh Jain, Rushi Panchal, Dilrose Pabla, Jaimini Patel, Mansi Khirwadkar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags