Author(s): Nowshin Nowaz Rumzhum, Mostafizur Rahman, AFM Rafiu-Ul Islam

Email(s): hasanmostafiz@yahoo.com

DOI: Not Available

Address: Nowshin Nowaz Rumzhum, Md. Mostafizur Rahman*, AFM Rafiu-Ul Islam
Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, Bangladesh
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2012


ABSTRACT:
Crude ethanolic extract of flowers of Couroupita guianensis Aubl. (Family: Lecythidaceae) was evaluated for central nervous system (CNS) depressant effects using a number of neuropharmacological experimental models in Swiss-albino mice. The extract produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field and hole cross studies. Further, at the same dose level the extract inhibited acetic acid-induced writhing in mice in dose-dependent manner. These results suggest that the extract possess CNS depressant activity, which support the traditional uses of Couroupita guianensis


Cite this article:
Nowshin Nowaz Rumzhum, Mostafizur Rahman, AFM Rafiu-Ul Islam. CNS Depressant Effect of Crude Ethanolic Extract of Flowers of Couroupita guianensis Aubl. in Swiss-albino Mice. Research J. Pharm. and Tech. 5(5): May2012; Page 615-618.


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DOI: 10.5958/0974-360X 

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