Author(s): M. Surendra, T. Venkateswara Rao, K. Lokeswara Reddy, A. Ramesh Babu

Email(s): tv_rao2@yahoo.com

DOI: Not Available

Address: M. Surendra*, T. Venkateswara Rao, K. Lokeswara Reddy, A. Ramesh Babu
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (D.t), Andhra Pradesh-522101, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012


ABSTRACT:
Microencapsulation by emulsification –ionic gelation technique is an approach to achieve controlled release of drug and mucoadhesive microcapsules were designed to improve the absorption and bioavailability of drug. Microcapsules of Aceclofenac were formulated by employing sodium alginate, two natural polymers-gum kondagogu and gum karaya. The prepared microcapsules were free flowing, discrete spherical shape was characterised by scanning electron microscopy (SEM). Microencapsulation efficiency was in the range of 60-80% and they exhibited good mucoadhesive property. Invitro dissolution data revealed that formulations exhibit the zero order kinetics and followed non-fickian diffusion transport mechanism. In-vitro release profile of formulation (F3) was found similar to that of marketed formulation. Pre-clinical pharmacological activity i.e. analgesic activity was conducted and optimized formulation exhibited the significant analgesic activity Mucoadhesive microcapsules prepared with sodium alginate, gum karaya and gum kondagogu found to be suitable for oral controlled release.


Cite this article:
M. Surendra, T. Venkateswara Rao, K. Lokeswara Reddy, A. Ramesh Babu. Formulation and Evaluation of Mucoadhesive Microcapsules of Aceclofenac for Oral controlled release by Emulsification-gelation Technique. Research J. Pharm. and Tech. 5(4): April 2012; Page 525-532.

Cite(Electronic):
M. Surendra, T. Venkateswara Rao, K. Lokeswara Reddy, A. Ramesh Babu. Formulation and Evaluation of Mucoadhesive Microcapsules of Aceclofenac for Oral controlled release by Emulsification-gelation Technique. Research J. Pharm. and Tech. 5(4): April 2012; Page 525-532.   Available on: https://rjptonline.org/AbstractView.aspx?PID=2012-5-4-7


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DOI: 10.5958/0974-360X 

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