Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain
Pankaj P. Ostwal1*, Yogesh L. Jadhav2, Mayur S. Jain3, Sumit P. Jain3
1I. B. S. S. College Of Pharmacy, Malkapur Dist. Buldhana.
2Manav Bharti University, Solan (H.P)
3Tapi Valley College of Pharmacy, Faizpur, Dist. Jalgaon.
Volume - 5,
Issue - 4,
Year - 2012
The aim of this study was to prepare bi-layer tablet of Paracetamol and Ibuprofen (IB) for the effective treatment of Fever, joint pain, body pain. Paracetamol and IB were formulated as immediate and sustained release layer respectively. Paracetamol was formulated as immediate release layer by using various disintegrants like starch,Crospovidone.IB was formulated by using hydrophilic matrix (hydroxypropylmethylcellulose [HPMC K4M]). The effect of concentration of hydrophilic matrix (HPMC K4M), binder (polyvinylpyrollidone [PVP K30]) and buffer (sodium bicarbonate). The dissolution study of sustained release layer showed that an increasing amount of HPMC or PVP K30 results in reduced IB release. The inclusion of buffer (sodium bicarbonate) enhanced the release of IB from sustained release layer. Bi-layer tablet was suitable for preventing direct contact of these two drugs and thus to minimizes the pill burden of the patient with greater efficiency of NSAID.
Cite this article:
Pankaj P. Ostwal, Yogesh L. Jadhav, Mayur S. Jain, Sumit P. Jain. Dissolution Profiling of Bilayered Conventional Release Paracetamol and Sustained Release Ibuprofen (By Simultaneous Estimation Method UV). Research J. Pharm. and Tech. 5(4): April 2012; Page 490-493.