Author(s): Budhwani Ashok K., Shrivastava B., Singhai A.K., Gupta Prashant

Email(s): ashokbudhwani@yahoo.com

DOI: Not Available

Address: Budhwani Ashok K. 1*, Shrivastava B.2, Singhai A.K.3, Gupta Prashant1
1Daksh Institute of Pharmaceutical Science, Chhatarpur (M.P.)
2Jaipur National University, Jaipur (Raj)
3Laxmi Narayan College of Pharmacy, Bhopal (M.P.)
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012


ABSTRACT:
To evaluate the antihyperglycemic activity of ethanolic extract of leaves of Dioscorea japonica in STZ induced diabetic rats. STZ-induced (60 mg/kg, i.p.) diabetic mice given ethanolic leaf extract (200, 300, 350 and 400 mg/kg, p.o.,n=6) of D. japonica and in vehicle (distilled water, 10 ml/kg.,p.o.) and in standard drug metformin (500 mg/kg.,p.o.) respectively for 14 days. The dose of 350 mg/kg body weight (bw) reduced the fasting blood glucose (FBG) level by 6.0% within 1 hr, whereas, the peak blood glucose at 1 hr during glucose tolerance test (GTT) was reduced by 17.1% in normal rats. The same dose of ethanolic extract reduced FBG by 13.0% and improved glucose tolerance by 37.2 and 60.6% at 1and2 h, respectively, during GTT in STZ-diabetic rats. The dose of 350 mg/kg body weight of ethanolic extract in 14-day treatment of a group of STZ-diabetic rats produced 73.3% fall in FBG level and no sugar was observed in fasting urine. It brought about fall in the level of total cholesterol (TC) by 49.3% with increase of 30.3% in high-density lipoprotein (HDL) and decrease of 71.9 and 28.7% in low-density lipoprotein (LDL) and triglycerides (TG) levels, respectively. The ethanolic leaf extract of D. japonica (200, 300, 350 and 400 mg/kg, p.o) showed significant (P<0.01) reduction of serum glucose level in STZ-induced diabetic mice at 14th day. It is concluded that D. japonica has significant antihypergycemic activity as it lowers serum level of glucose in diabetic mice and significantly increase glucose tolerance


Cite this article:
Budhwani Ashok K., Shrivastava B., Singhai A.K., Gupta Prashant. Antihyperglycemic activity of ethanolic extract of leaves of Dioscorea japonica in STZ-induced diabetic rats. Research J. Pharm. and Tech. 5(4): April 2012; Page 553-557.


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