Author(s): Sanjay S. Jain, Hemanshu V. Agarwal, Pramod S. Jagtap, Neha M. Dand, Kisan R. Jadhav, Vilasrao J. Kadam

Email(s): sanjayjain1000@yahoo.co.uk / sjsanjayjain999@gmail.com

DOI: Not Available

Address: Sanjay S. Jain*, Hemanshu V. Agarwal, Pramod S. Jagtap, Neha M. Dand, Dr. Kisan R. Jadhav, Dr. Vilasrao J. Kadam
Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Sector-8, C.B.D., Belapur, Navi Mumbai- 400614, Maharashtra, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012


ABSTRACT:
Certain diseases have predictable cyclic rhythms and that the timing of medication regimens can improve outcome in selected chronic conditions. These condition demand for release of drug after lag time i.e. chronopharmacotherapy of disease which shows circadian rhythm in their pathophysiology. Pulsatile system is amongst one of them and gaining a lot of interest as it is increasing patient compliance by means of providing time and site-specific drug delivery system, thus providing special and temporal delivery. Pulsed or pulsatile drug release is defined as the rapid and transient release of a certain amount of drug molecules within a short time-period immediately after a predetermined off-release period. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system; stimuli induced PDDS in which release is controlled by the stimuli like the temperature, pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. The current article focuses on the diseases requiring PDDS, marketed technologies, method of formulation of existing systems, recent advances, advantages and limitation of PDDS. Pulsatile drug delivery is one such systems that by delivering drug at the right time, right place and in right amounts, holds good promises of benefit to the patients suffering from chronic problems like arthritis, myocardial infarction, angina pectoris, asthma, hypertension etc.


Cite this article:
Sanjay S. Jain, Hemanshu V. Agarwal, Pramod S. Jagtap, Neha M. Dand, Kisan R. Jadhav, Vilasrao J. Kadam. Pulsatile drug delivery system (PDDS): A Brief Overview. Research J. Pharm. and Tech. 5(4): April 2012; Page 449-461.


Recomonded Articles:

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Ram S Sakhare, Ashish B Roge, RL Bakal, MA Channawar, AV Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): P.S Gangane, S. B. Sapkal, A.S. Welankiwar, P.S. Magar, D.V. Bhusari

DOI: 10.5958/0974-360X.2015.00067.0         Access: Open Access Read More

Author(s): Mayur D. Doshi, Niranjan D. Chivate, Anuradha N. Chivate, Tejaswini Shingate

DOI: Not Available         Access: Open Access Read More

Author(s): Mangesh A. Bhutkar, Swapna R. Khochage, Snehal D. Mali, Sadhana B. Todkar

DOI: Not Available         Access: Open Access Read More

Author(s): Rebeccar. George, Anitha Mangesh, Dhanraj

DOI: 10.5958/0974-360X.20362817.00658.8         Access: Open Access Read More

Author(s): Tom Damien, Someshwara Rao B., Ashok Kumar P., Amith S. Yadav, Suresh V. Kuikarni

DOI:         Access: Open Access Read More

Author(s): Nagarathna PKM, Harsha Vardhini N, Babiker Bashir, Mahesh kumar C S, Chandanam Sreedhar

DOI: 10.5958/0974-360X.2019.00683.8         Access: Closed Access Read More

Author(s): Pradip P Gade, Mohd. Majid Iqbal, K Sreenivasa Rao

DOI:         Access: Open Access Read More

Author(s): Nabarun Mukhopadhyay, Sampath. V, Sameer Pai, U. V. Babu, Richard Lobo

DOI: 10.5958/0974-360X.2019.00068.4         Access: Closed Access Read More

Author(s): Sandip Zine, Shweta A. Patankar, Sushmita S. Raopati

DOI: 10.5958/0974-360X.2018.00588.7         Access: Open Access Read More

Author(s): Nikunja B. Pati, V R M Gupta, Swapna Velivela

DOI: 10.5958/0974-360X.2018.00759.X         Access: Open Access Read More

Author(s): Hema Jaiswal, Vaseem Ahamad Ansari, J. N. Pandit, Farogh Ahsan

DOI: 10.5958/0974-360X.2019.00535.3         Access: Closed Access Read More

Author(s): Sunam Saha, Kartik Kaushik, Rajat Garg

DOI: 10.5958/0974-360X.2020.00170.5         Access: Closed Access Read More

Author(s): D Kilimozhi, V Parthasarathy, Manavalan R

DOI: Not Available         Access: Open Access Read More

Author(s): Susmit S. Diggikar, Tanaji D. Nandgude, Sushilkumar S. Poddar

DOI: 10.5958/0974-360X.2018.00006.9         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags