Author(s): Sahu Chandra Mohan, Chandira R. Margret, Vaidya Shivani, Tiwari D.K., Sharma Sarvesh, S.J. Ingale, Singhai A.K.

Email(s): cms_23031984@rediffmail.com

DOI: Not Available

Address: Sahu Chandra Mohan1*, Chandira R. Margret2, Vaidya Shivani1, Tiwari D.K.1, Sharma Sarvesh1, S.J. Ingale1 and Singhai A.K.1 1Department of Pharmaceutics, Lakshmi Narain College of Pharmacy, Bhopal (M.P.) India 2Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Salem, (T.N.) India *Corresponding author

Published In:   Volume - 5,      Issue - 3,     Year - 2012


ABSTRACT:
The present work aim is to formulate and evaluate floating tablets of Diltiazem Hydrochloride for its physicochemical properties and in-vitro buoyancy studies using an effervescent approach for gastro retentive drug delivery system. Diltiazem Hydrochloride effervescent floating tablets were developed direct compression technique in twelve different formulations (F1 to F12) by employing different grades of polymers and effervescent agents such as sodium bicarbonate and citric acid. Formulation F3, F6 and F9 containing HPMC K4M, HPMC K15M and Ethylcellulose showed good Buoyancy lag time of 150,132 and 170 sec. respectively and it remained float for more than 12 hr in the release medium.


Cite this article:
Sahu Chandra Mohan, Chandira R. Margret, Vaidya Shivani, Tiwari D.K., Sharma Sarvesh, S.J. Ingale, Singhai A.K.. Design and In-vitro Buoyancy Evaluation of Floating Tablets of Diltiazem Hydrochloride. Research J. Pharm. and Tech. 5(3): Mar.2012; Page 337-341.


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DOI: 10.5958/0974-360X 

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