Author(s): Sandeep Reddy CH, Sree Kumar Reddy G., Manoj Kumar Mahto, Pavan Kunala, Chaitanya Kanth R.

Email(s): sandeep97@gmail.com

DOI: Not Available

Address: Sandeep Reddy CH1*, Sree Kumar Reddy G.2, Manoj Kumar Mahto3, Pavan Kunala4, Chaitanya Kanth R.5
1Dept. of Pharmacology, MLR institute of Pharmacy, Dundigal, Hyderabad, India.
2Dept. of Pharmaceutical Chemistry, JNTU-OTRI, Anantapur, India
3Dept. of Bioinformatics, Acharya Nagarjuna University, Guntur, AP, India.
4Dept. of Pharmaceutical Sciences, Rao’s college of Pharmacy, Nellore, AP, India.
5Dept. of Pharmaceutical Analysis, Vishnu College of Pharmacy, Bhimavaram, India.
*Corresponding author

Published In:   Volume - 5,      Issue - 3,     Year - 2012


ABSTRACT:
Enzyme Acetyl cholinesterase (AChE) catalyzes the neurotransmitter acetylcholine (ACh) at synaptic clefts of the neurons. Apart from its hydrolyzing activity it is also known to play an important role in amyloid formation thus causing Alzheimer’s disease (AD). AD is associated with significant loss of cholinergic neurons and reduced levels of ACh, which significantly impairs learning and memory processes. Acetyl cholinesterase inhibitors (ACIs) are one of the widely used drugsfor the treatment of mild to moderate Alzheimer’s dementia. Acetyl cholinesteraseinhibitors improve the neurological behavior by increasing availability of acetylcholine at synapse in the presence of intact cholinergic neurons. So identifying potent AChE inhibitors may declineneuro degeneration in AD patients. In this computational study, several novel AChE inhibitors were designed and optimized in the software Hyperchem. Also, these inhibitors were docked with the AChE in FLExX docking program and toxicity studies were conducted using OSIRIS property explorer. Here, the ligand 15 has shown better interaction and high binding affinity with AChE.


Cite this article:
Sandeep Reddy CH, Sree Kumar Reddy G., Manoj Kumar Mahto, Pavan Kunala, Chaitanya Kanth R. Insilico Design and Discovery of Some Novel Ache Inhibitors for Treatment of Alzheimer’s Disorder. Research J. Pharm. and Tech. 5(3): Mar.2012; Page 424-427.


Recomonded Articles:

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available         Access: Open Access Read More

Author(s): R.D. Khose, A.V. Jaydeokar, U.S. Patil, P.P. Bagul, D.D. Bandawane, P.D. Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vasudev Pai, Chandrashekar K. S, C. S. Shreedhara, Aravinda Pai

DOI: 10.5958/0974-360X.2017.00628.X         Access: Open Access Read More

Author(s): Nagarathna PKM, Harsha Vardhini N, Babiker Bashir, Mahesh kumar C S, Chandanam Sreedhar

DOI: 10.5958/0974-360X.2019.00683.8         Access: Open Access Read More

Author(s): Gopinath G, Thirumal M, P. R. Kumar

DOI: 10.5958/0974-360X.2020.00362.5         Access: Closed Access Read More

Author(s): Tamilselvan. M, Tamilanban. T, V. Chitra

DOI: 10.5958/0974-360X.2020.00534.X         Access: Closed Access Read More

Author(s): Bhavana Deshmukh, Swati Dubey, Ravindra Kumar Pandey, Shiv Shankar Shukla

DOI: 10.5958/0974-360X.2018.00246.9         Access: Open Access Read More

Author(s): Balasankar Karavadi, Martina V.

DOI: 10.5958/0974-360X.2018.00268.8         Access: Open Access Read More

Author(s): Zein Alabdeen Khdar, Faten Sliman, Mohammad Kousara

DOI: 10.5958/0974-360X.2019.00939.9         Access: Open Access Read More

Author(s): Nillohit Mitra Ray, Rahul Singh, Joginder Singh, Shipra Bhati, Vikas Kaushik

DOI: 10.5958/0974-360X.2020.00150.X         Access: Closed Access Read More

Author(s): Sailaja Maddhuri, Praveen Kumar Vemuri, Jahnavi Tatineni, Jharna Puppala

DOI: 10.5958/0974-360X.2020.00113.4         Access: Closed Access Read More

Author(s): Avuthu Sai Sheela, Mukthinuthalapati Mathrusri Annapurna

DOI: 10.5958/0974-360X.2019.00964.8         Access: Open Access Read More

Author(s): Geetha. P, Vaishnavi Raksha. R, Mohamed Ishak. J , Shanmugasundaram. P

DOI: 10.5958/0974-360X.2017.00733.8         Access: Open Access Read More

Author(s): Aswathy, Balasankar Karavadi, Nisha H

DOI: 10.5958/0974-360X.2017.00355.9         Access: Open Access Read More

Author(s): S. Akilashree., Brindha Devi. P

DOI: 10.5958/0974-360X.2019.00528.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags