Author(s): Shrikrishna Baokar, Vinod Pawar, R.N. Patil, Rashmi Jagatap, Netrali Ekatpure

Email(s): krishnabaokar@gmail.com

DOI: Not Available

Address: Shrikrishna Baokar*, Vinod Pawar, R.N. Patil, Rashmi Jagatap and Netrali Ekatpure
Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk II), Tal-Baramati, Dist- Pune, Maharashtra, India- 413115
Corresponding author

Published In:   Volume - 5,      Issue - 2,     Year - 2012


ABSTRACT:
A Simple, sensitive, specific, spectrophotometric method has been developed for the detection of Sildenafil citrate in pure form and Pharmaceutical formulations. The optimum condition for the analysis of the drug was established. Sildenafil citrate exhibiting absorption at 228nm and obeyed beers law in the concentration range 10 to 50µg/ml. The correlation coefficient was found to be 0.9998 and slope of line was found to be 0.07877. The percent S.D. for intra assay precision of the method was found to be 1.9976% whereas Inter assay precision was found to be 0.8332%. The sample solution was stable up to 24 hours. The assay results were found to be in good agreement with label claim. The degradation study was checked at different conditions like with acid, alkali, dry heat, oxidative and photolytic. All the results found in degradation study were satisfactory. So this proposed method was simple sensitive, precise, quick and useful for routine quality control.


Cite this article:
Shrikrishna Baokar, Vinod Pawar, R.N. Patil, Rashmi Jagatap, Netrali Ekatpure. Validation of Simple and Rapid UV-Spectrophotometric Method with Stress Degradation Study for Sildenafil Citrate. Research J. Pharm. and Tech. 5(2): Feb. 2012; Page 214-218.


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DOI: 10.5958/0974-360X 

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