Author(s): Palled M. S.., Lohar V. R., Kalekar M. C., Patil P. B., Bhat A. R

Email(s): maheshpalled@rediffmail.com

DOI: Not Available

Address: Palled M. S.*., Lohar V. R., Kalekar M. C., Patil P. B., Bhat A. R.
Department of Pharmaceutical Chemistry, K. L.E.U’s College of Pharmacy, Belgaum
Corresponding author

Published In:   Volume - 5,      Issue - 2,     Year - 2012


ABSTRACT:
Research on benzimidazole and thiazolidine-4-one and their synthetic analogs have been revealed to posses wide range of antimicrobial activity. It was our interest to make novel derivatives of fused benzimidazole, thiazolidine-4-one nuclei and evaluate them for antimicrobial activity. Formic acid was treated with o-phenylenediamine to obtain benzimidazole which was treated with CH3I for N-methylation. Later this compound was subjected for Vilsmeier-Haack Reaction, followed by formation of Schiff bases on treatment with various aromatic amines. The various Schiff bases were further treated with thioglycolic acid to obtain thaizolidine-4-one derivatives. (Scheme-I). In another (Scheme-II) N-methyl substituted benzimidazole-2-carbohydrazide (Vilsmeier-Haack Reaction product) followed by acidification, esterification and hydrazide formation. Finally hydrazide treated with different aldehydes to obtain carbohydrazide derivatives. The structures of synthesized derivatives were identified and characterized by m.p, TLC, IR, 1HNMR and Mass Spectroscopy. The synthesized compounds BA-SA, BA-SN, AH-BR and AH-CL have shown significant antibacterial activity against E. coli, E.fecalis, Klebsiella and S. aureus and BA-SA, BA-SN, BA-CL and AH-CL shown significant antifungal activity against C. albicans and A. niger.


Cite this article:
Palled M. S.., Lohar V. R., Kalekar M. C., Patil P. B., Bhat A. R. Synthesis of 1,2,3,4-[ 1-N- Methyl Benzimidazole] 3-Phenyl Substituted Thiazolidine, 4-One and Carbohydrazide Derivatives for Antimicrobial Activity. Research J. Pharm. and Tech. 5(2): Feb. 2012; Page 249-252.


Recomonded Articles:

Author(s): Umesh Kumar, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh, Vivek Gupta

DOI: 10.5958/0974-360X.2017.00425.5         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): Pooja Thakur, Chirag Chopra, Daljeet Singh Dhanjal, Reena Singh Chopra

DOI: 10.5958/0974-360X.2017.00466.8         Access: Open Access Read More

Author(s): Chandak BG, Sarpate RV, Chatterjee NR, Baheti KG

DOI: Not Available         Access: Open Access Read More

Author(s): Md Kamal Hossain, Kamrun Nahar, Parisa Shokryazdan, Norhani Abdullah, Kaiser Hamid, Mohammed Faseleh Jahromi

DOI: 10.5958/0974-360X.2017.00530.3         Access: Open Access Read More

Author(s): S. Krishnakumar, R. Divya, N.R. Kanchana Devi, G. Keerthana, A. Ancy Judi

DOI: 10.5958/0974-360X.2017.00234.7         Access: Open Access Read More

Author(s): Nadeem Siddiqui, Waquar Ahsan, M. Shamsher Alam, Andalip, Bishmillah Azad, M. Jawaid Akhtar

DOI: Not Available         Access: Open Access Read More

Author(s): Kulkarni Anup, Kale Mohan, Sarode Suraj, Firke Sandip, Firke Bhushan, Warke Prashant

DOI: Not Available         Access: Open Access Read More

Author(s): Kajal Pawar, Poonam Kumbhar, Vishal Shah

DOI: 10.5958/0974-360X.2017.00463.2         Access: Open Access Read More

Author(s): Ankit Patel, Pankaj Kushwah, Sujit Pillai, Ajay Raghuvanshi, Nitin Deshmukh

DOI: 10.5958/0974-360X.2017.00013.0         Access: Open Access Read More

Author(s): S. Dhakshanamoorthy, N. Sri Gayathrai Devi, M. Murali Krishnan, M. N. Arumugham

DOI: 10.5958/0974-360X.2019.00083.0         Access: Open Access Read More

Author(s): El harti Jaouad, Adouani Badr, Benmoussa Adnane, Ansar M’hammed, Taoufik Jamal

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags