Author(s): Carla Caddeo, Maria Manconi, Donatella Valenti, Anna Maria Maccioni, Anna Maria Fadda, Chiara Sinico

Email(s): manconi@unica.it

DOI: Not Available

Address: Carla Caddeo, Maria Manconi*, Donatella Valenti, Anna Maria Maccioni, Anna Maria Fadda, Chiara Sinico
Dept. Scienze della Vita e dell’Ambiente, Sezione Scienze del Farmaco, University of Cagliari, CNBS, Via Ospedale 72, 09124 Cagliari, Italy
*Corresponding Author

Published In:   Volume - 5,      Issue - 12,     Year - 2012


ABSTRACT:
In this work we focused on how the concentration of Labrasol® and preparation method of phospholipid vesicles might influence their physico-chemical features and skin delivery performances. Penetration Enhancer-containing Vesicles (PEVs) were prepared using caprylcaproyl macrogol-8 glyceride (Labrasol®, HLB 14), a solubilizer/penetration enhancer for topical formulations. A cheap and unpurified commercial mixture of phospholipids, fatty acids and triglycerides (Phospholipon® 50) was used to incorporate minoxidil (2% w/v). During the preparation, labrasol was added at different concentrations in the lipid phase or mixed with the water phase. The film hydration method was used, followed by sonication, when appropriate. The effects that these variables might have on PEVs colloidal characteristics were investigated. Multi- and oligolamellar vesicles were obtained, depending on the production procedure, around 100 nm, negatively charged (~ -60 mV), able to incorporate minoxidil in good yields (up to 74%), and stable during storage. Further, vesicles were evaluated for ex vivo (trans)dermal delivery through new born pig skin, showing improved minoxidil local accumulation, influenced by labrasol concentration and insertion in the aqueous or lipid phase of the vesicular formulations. Overall, it can be assumed that PEVs enhanced drug transport through the skin barrier thanks to a synergic effect of vesicles and labrasol. The proposed approach based on vesicular nanocarriers may hold promising therapeutic value for treating hair growth disorders, by increasing cutaneous minoxidil bioavailability and reducing transdermal permeation.


Cite this article:
Carla Caddeo, Maria Manconi, Donatella Valenti, Anna Maria Maccioni, Anna Maria Fadda, Chiara Sinico. The Role of Labrasol® in the Enhancement of the Cutaneous Bioavailability of Minoxidil in Phospholipid Vesicles. Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1563-1569.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Saranya, Parthasarathy V, Hariprasad B, Shobha Rani H

DOI: 10.5958/0974-360X.2016.00233.X         Access: Open Access Read More

Author(s): Ankita Chatterjee, Jayanthi Abraham

DOI: 10.5958/0974-360X.2016.00125.6         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao US, San San Oo, Nurul Liana Sabrin, Norsyahira Syazwana Mohd Razali, Khairunnisa Khalid, Nurul Farihah Mohamed Nadzari, Thant Zin

DOI: 10.5958/0974-360X.2017.00065.8         Access: Open Access Read More

Author(s): Yarnykh T.G., Azarenko Iu. M., Buryak M.V., Bubilieva L. A.

DOI: 10.5958/0974-360X.2016.00115.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags