Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Sustained Ophthalmic Delivery of Moxifloxacin Hydrochloride from an pH Triggered in Situ Gelling System

Author(s): S.K. Gupta, I.J. Singhvi

Email(s): garg_s.kumar@yahoo.com

DOI: Not Available

Address: S.K. Gupta1* and I.J. Singhvi2
1Ph. D. Research Scholar, Pacific College of Pharmacy, Udaipur, Rajasthan
2Pacific College of Pharmacy, Udaipur, Rajasthan
*Corresponding Author

Published In:   Volume - 5,      Issue - 12,     Year - 2012

 View HTML        View PDF

ABSTRACT:
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent moxifloxacin hydrochloride, based on the concept of pH triggered in situ gelation. Carbopol 940 was used in different concentrations (0.3-0.5 w/v) as the gelling agent in combination with HPMC E50 LV (Hydroxy Propyl Methyl Cellulose) that acted as a viscosity-enhancing agent. The primary criteria for formulation optimization were gelling capacity and rheological behaviour. In addition, formulations were evaluated for pH, and antimicrobial efficacy and drug release. The clarity, pH, gelation in simulated tear fluid and rheological properties of the optimized formulations were satisfactory. In vitro release studies indicated that the Carbopol /HPMC solution retained the drug better than the Carbopol or HPMC solutions alone. The formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a period of time. These results demonstrate that the developed system is an alternative to conventional ophthalmic drops, patient compliance, industrially oriented and economical.


Keywords:

Cite this article:
S.K. Gupta, I.J. Singhvi. Sustained Ophthalmic Delivery of Moxifloxacin Hydrochloride from an pH Triggered in Situ Gelling System. Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1538-1542.


Recomonded Articles:

Medicinal Plants from Solanaceae Family

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available         Access: Open Access Read More

A comparative, Bioequivalence study to evaluate the safety and pharmacokinetic profile of single dose Ivabradine 7.5mg Tablets in healthy, adult, human subjects under fasting condition.

Author(s): Amol K Choulwar, Ashish A. Mungantiwar, Meena Chintamaneni

DOI: Not Available         Access: Open Access Read More

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Oral Gel Containing Miconazole Nitrate for Oral Candidiasis

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Role of Terminalia chebula on Gastrointestinal Mucosa

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Design and Characterization of Valsartan Co-Crystals to Improve its Aqueous Solubility and Dissolution Behavior

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Formulation of PLGA Polymeric Nanosuspension containing Pramipexole Dihydrochloride for improved treatment of Parkinson’s Diseases

Author(s): I. Somasundaram, B.V. Nagarjuna Yadav, S. Sathesh Kumar

DOI: 10.5958/0974-360X.2016.00155.4         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Fast Melt-Away Wafers Using Selected Polymers

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Qualitative Phytochemical Screening and In-vitro Anthelmintic Activity of Adhatoda vasica (Acanthaceae)

Author(s): Shabi Ruskin, R., S. Ajina

DOI: 10.5958/0974-360X.2017.00083.X         Access: Open Access Read More

Formulation and Evaluation of Irbesartan nanosuspension for Dissolution Enhancement

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Study of Leachate Characterization in Landfill by Municipal Solid Waste

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride.

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Phytochemical Analysis and Antimicrobial Activity of Ethonolic Leaf Extract of Ficus racemosa Linn

Author(s): T. Thilagavathi, G. Kathiravan

DOI: 10.5958/0974-360X.2017.00107.X         Access: Open Access Read More

Preparation and Characterization of Lercanidipine Hydrochloride Inclusion complex with β-cyclodextrin and effect of Complexation on Solubility and Dissolution

Author(s): Farhatjahan I. Shaikh, Meenakshi B. Patel, Naazneen I. Surti, Vandana B. Patel

DOI: 10.5958/0974-360X.2017.00189.5         Access: Open Access Read More

A Review on Transbuccal Drug Delivery System and its Commercially Available Products

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Simultaneous RP-HPLC Method for the Estimation of the Emtricitabine, Tenofovir Disoproxil Fumerate and Efavirenz in Tablet Dosage Forms

Author(s): N Appala Raju, Shabana Begum

DOI:         Access: Open Access Read More

Factors Influencing Rifampicin Autoinduction in Adult Pulmonary Tuberculosis Patients

Author(s): Saranya, Parthasarathy V, Hariprasad B, Shobha Rani H

DOI: 10.5958/0974-360X.2016.00233.X         Access: Open Access Read More

Comparative Study of Cleaning Efficacy of Different Concentrations of Sodium Hypochlorite on Nickel-Titanium Endodontic Instruments.

Author(s): Kaviena Baskaran, James D. Raj, Joshua Ng Chor Yang

DOI: 10.5958/0974-360X.2017.00018.X         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Design, Synthesis, Characterization and Antioxidant activity of Novel Benzothiazole and Coumarin based 6-(3, 5-dimethylpyrazol-1-yl) pyridazin-3-one Derivatives
The Thermodynamic parameters of Chlorpromazine hydrochloride partitioning into Dimyrstoylphosphatidylcholine liposomes
The regulatory role of Neurotransmitters in Orexin B induced Nucleus Accumbens dependent alcohol ingestion in Wistar albino rats
Compounding practice in a developing Country: A Case study of divided Powder in Indonesia
Estimation of Anti-Diabetic property of Holarrhena pubescens by In Vitro method using L6 rat Skeletal Muscle Cell Lines
Synthesis, Spectral Characterization and Anticancer activity of Novel Pyrimidine Derivatives
Colon Specific Drug Delivery Systems – Different Systems and Approaches: A Review
Role of Dietary Supplements in Sports Performance
Bora Rice: Natural polysaccharide polymer for drug delivery
An outline on Curcumin: Its pro-liposome and Liposome Formulations
An Insight on pain modulation with Gender and Obesity: A Systematic Review
CNS and COVID-19: Neurological symptoms of Hospitalized Patients with Coronavirus in Iraq: a surveying case sequences study
Comparative Studies of the Amino acids profile Persicaria hydropiper L. Delarbre and Persicaria minor Hunds., growing in the Voronezh region (Russia)
Association of Leptin in Diabetes Mellitus and Obesity
Development and Evaluation of topical Emulgel of Aspirin using different Polymeric Bases
Formulation and Evaluation of Microemulsion containing Anti-Hypertensive Drug
Studying the prevalence of genital Chlamydia trachomatis IgG serum antibodies and associated risk factors in heterosexual men attending Tishreen University Hospital, Syria
Effect of Encapsulated Lactobacillus rhamnosus GG in Antibiotic associated diarrhea in Albino Wistar rat model
Pharmacognostic Evaluation and Standardization of the leaves of Mimosa pudica, leaves of Murraya koenigii and root of Asparagus racemosus
Quantitative Analysis of Combined Analgetic Tablets

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 3466
Yesterday: 22819
Total: 5341056