Ashish D. Mishra, Dignesh M. Khunt, Aakash H Ghayal, C N Patel, Dinesh R. Shah
Ashish D. Mishra1, Dignesh M. Khunt1, Aakash H Ghayal1, C N Patel2, Dinesh R. Shah1
1Maliba Pharmacy College, Bardoli-Mahuva Road, Dist. Surat (Gujarat), India - 394 350
2Sarvajanik Pharmacy College, Mehsana (Gujarat), India
Volume - 5,
Issue - 12,
Year - 2012
The present study focuses on the formulation of ethosomal gel of felodipine, an antihypertensive drug, for delivery as a carrier for transdermal application. The ethosomes were prepared using different concentrations of phospholipids (2 – 5 %), ethanol (20 – 50 %), felodipine (5 %) and water. They were optimized using 32 full factorial designs to study the effect of independent variables, i.e. concentration of ethanol (X1) and lecithin (X2) on dependent variables like % entrapment efficiency (%EE) and % drug release at 24 ((Q24). The prepared ethosomes were characterized for % entrapment efficiency and in-vitro drug release (by modified Franz diffusion cell). The drug release profile exhibited Higuchi’s and zero order kinetics. From the regression analysis, it was observed that all three independent variables had significant effect on response variables. Formulation was optimized using contour plot and response surface plot. The optimized formulation was found to be FS11 containing high concentration of ethanol (40 %) and medium concentration of lecithin (4%). The optimized formulae were evaluated for assay, particle size, distribution and shape, zeta potential, skin retention and stability. Ethosomal gel was prepared by incorporation of ethosomal suspension (FS11) into gel base. The ethosomal gel was characterized for physical appearance, pH, content uniformity, rheological behaviour, skin-retention, in-vitro and in-vivo drug release and stability. Results suggest that ethosomal gel can enhance delivery of felodipine through skin and can improve bioavailability of the drug.
Cite this article:
Ashish D. Mishra, Dignesh M. Khunt, Aakash H Ghayal, C N Patel, Dinesh R. Shah. Formulation and Optimization of Ethosomes for Transdermal Delivery of Felodipine. esearch J. Pharm. and Tech. 5(12): Dec. 2012; Page 1509-1517.