Author(s): Saroj Kumar Raul, B.V.V Ravi kumar, Ajaya Kumar Pattnaik

Email(s): saroj.raul@rediffmail.com

DOI: Not Available

Address: Saroj Kumar Raul1*, B.V.V Ravi kumar2, Ajaya Kumar Pattnaik3
1M. R. College of Pharmacy, Phool-Baugh, Vizianagaram, A.P, India.
2Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India.
3Departments of Chemistry, Ravenshaw University, Cuttack, Orissa, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 12,     Year - 2012


ABSTRACT:
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Tadalafil in pharmaceutical dosage form. Isocratic elution at a flow rate of 1.0 mL min -1 was employed on a Symmetry C18 column at ambient temperature. The mobile phase consisted of acetonitrile: buffer 50:50 (v/v) and the detection wavelength was at 284 nm. Linearity was observed in concentration range of 20-70 µg/mL. The retention time for Tadalafil was 2.98 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Tadalafil in pharmaceutical dosage forms.


Cite this article:
Saroj Kumar Raul, B.V.V Ravi kumar, Ajaya Kumar Pattnaik. A RP-HPLC Method Development and Validation for the Estimation of Tadalafil in Bulk and Pharmaceutical Dosage Forms. Research J. Pharm. and Tech. 5(12): Dec. 2012; Page 1573-1576.


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DOI: 10.5958/0974-360X 

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