Author(s): El harti Jaouad, Ansar M’hammed, Lmimouni Badr, Benomar Ali, Taoufik Jamal

Email(s): ja.elharti@um5s.net.ma

DOI: Not Available

Address: El harti Jaouad1*, Ansar M’hammed1, Lmimouni Badr2, Benomar Ali3, Taoufik Jamal1
1Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, BP 6203, Rabat Institute, University Mohammed V Souissi, Rabat, Morocco.
2Laboratory of Parasitology-Mycology, Instruction Military Hospital Mohammed V, Rabat, Morocco.
3Research Center for Clinical Epidemiology and Therapeutic Trials, Faculty of Medicine and Pharmacy, BP 6203, Rabat Institute, University Mohammed V Souissi, Rabat, Morocco.
*Corresponding Author

Published In:   Volume - 5,      Issue - 11,     Year - 2012


ABSTRACT:
The treatment of hydatidosis is primarily surgical but can cause morbidity or mortality, hence the interest in many cases of medical treatment whose main representative is albendazole. The efficacy of this compound against Echinococcus granulosus cysts is proved, but limited by its poor bioavailability. New potential prodrugs were synthesized and their protoscolicidal activity was tested in vitro. Although hydrogen N°1 is important for the albendazole activity, some derivatives have kept an activity relatively important


Cite this article:
El harti Jaouad, Ansar M’hammed, Lmimouni Badr, Benomar Ali, Taoufik Jamal. Synthesis and Scolicidal Activity of some Potential Prodrugs of Albendazole. Research J. Pharm. and Tech. 5(11): Nov. 2012; Page 1442-1445.


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