Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Antiepileptic Effects of Sapindus mukorossi in rats

Author(s): Pradeep Kumar Samal, Shani Sharaf, N.R. Beck, J.S. Dangi

Email(s): samalpharmacology@rediffmail.com

DOI: Not Available

Address: Pradeep Kumar Samal*, Shani Sharaf, N.R. Beck and J.S. Dangi
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh.
*Corresponding Author

Published In:   Volume - 5,      Issue - 11,     Year - 2012

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ABSTRACT:
Plant for the present studies was selected on the bases of literature review. Plant was collected from local market Bilaspur, Chhattisgarh, The collected leaves were powdered in grinder and extracts were prepared in ethanol and chloroform solvents. These extracts were used for further studies. Phytochemical studies had been performed on the extracts and it was found to have like saponin, Sterols, Fatty acids and oils and carbohydrate. Acute oral toxicity study of ethanolic extract of Sapindus mukorossi (EESM) was conducted in rat by using OECD guideline no.425 and it was found to safe up to the dose label of 2000mg/kg of body weight. In Maximal electro-shock (MES) induced model, dose of EESM (200 and 400mg/kg) show highly significant anticonvulsant activity, but dose of chloroform extract of Sapindus mukorossi (CESM) did not show any anticonvulsant activity as compared to control group. In Pentylenetetrazol (PTZ) model lower dose of EESM (200 and 400mg/kg) show good anticonvulsant activity as compared to control group. Locomotor study in actophotomotor extract of EESM exhibited the decreased motor activity in dose dependent manner, it is sign of sedation. ESM increase the threshold of MES induced convulsion in a dose dependent manner.


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Cite this article:
Pradeep Kumar Samal, Shani Sharaf, N.R. Beck, J.S. Dangi. Antiepileptic Effects of Sapindus mukorossi in rats. Research J. Pharm. and Tech. 5(11): Nov. 2012; Page 1417-1420.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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