Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Antiepileptic Effects of Sapindus mukorossi in rats

Author(s): Pradeep Kumar Samal, Shani Sharaf, N.R. Beck, J.S. Dangi

Email(s): samalpharmacology@rediffmail.com

DOI: Not Available

Address: Pradeep Kumar Samal*, Shani Sharaf, N.R. Beck and J.S. Dangi
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh.
*Corresponding Author

Published In:   Volume - 5,      Issue - 11,     Year - 2012

 View HTML        View PDF

ABSTRACT:
Plant for the present studies was selected on the bases of literature review. Plant was collected from local market Bilaspur, Chhattisgarh, The collected leaves were powdered in grinder and extracts were prepared in ethanol and chloroform solvents. These extracts were used for further studies. Phytochemical studies had been performed on the extracts and it was found to have like saponin, Sterols, Fatty acids and oils and carbohydrate. Acute oral toxicity study of ethanolic extract of Sapindus mukorossi (EESM) was conducted in rat by using OECD guideline no.425 and it was found to safe up to the dose label of 2000mg/kg of body weight. In Maximal electro-shock (MES) induced model, dose of EESM (200 and 400mg/kg) show highly significant anticonvulsant activity, but dose of chloroform extract of Sapindus mukorossi (CESM) did not show any anticonvulsant activity as compared to control group. In Pentylenetetrazol (PTZ) model lower dose of EESM (200 and 400mg/kg) show good anticonvulsant activity as compared to control group. Locomotor study in actophotomotor extract of EESM exhibited the decreased motor activity in dose dependent manner, it is sign of sedation. ESM increase the threshold of MES induced convulsion in a dose dependent manner.


Keywords:

Cite this article:
Pradeep Kumar Samal, Shani Sharaf, N.R. Beck, J.S. Dangi. Antiepileptic Effects of Sapindus mukorossi in rats. Research J. Pharm. and Tech. 5(11): Nov. 2012; Page 1417-1420.


Recomonded Articles:

Development and Screening of Anticonvulsant Polyherbal Formulation

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Newer Biologically Active Pyridines: A Potential Review

Author(s): Nadeem Siddiqui, Waquar Ahsan, M. Shamsher Alam, Andalip, Bishmillah Azad, M. Jawaid Akhtar

DOI: Not Available         Access: Open Access Read More

Screening of Antiepileptic Activity of Leaves of Sapindus trifoliatus Linn.

Author(s): Jennifer Fernandes, Bhat K.Ishwar, Fernandes Ronald

DOI: Not Available         Access: Open Access Read More

Pharmacological Investigation of Anticonvulsant Activity of Sesamum indicum Linn. 50% Ethanol Leaves Extract

Author(s): Praveen Kumar, Vijay Yadav, Vikash Chaurasia, V. Ch. Rao

DOI: Not Available         Access: Open Access Read More

Natural Anticonvulsants: A Review

Author(s): Surendra Nath Pandeya, Rajeev Kumar, Ashish Kumar Pathak

DOI:         Access: Open Access Read More

Antiepileptic Effects of Sapindus mukorossi in rats

Author(s): Pradeep Kumar Samal, Shani Sharaf, N.R. Beck, J.S. Dangi

DOI: Not Available         Access: Open Access Read More

Application of Topliss Modified Approach in the Design and Synthesis of GABA- Nergic Anticonvulsants

Author(s): RL Sawant, MS Bhatia

DOI:         Access: Open Access Read More

Antiepileptic Effects of Sapindus mukorossi in rats

Author(s): Pradeep Kumar Samal*, Shani Sharaf, N.R. Beck and J.S. Dangi

DOI: Not Available         Access: Open Access Read More

Solasodine: A Perspective on their roles in Health and Disease

Author(s): R. Kumar, M. I. Khan, M. Prasad, Badruddeen

DOI: 10.5958/0974-360X.2019.00432.3         Access: Open Access Read More

Facilitatory effect of Piperine on the Anticonvulsant effect of Sodium valproate against Pentylenetetrazole induced Seizures in mice

Author(s): Sooraj Surendran, Merin Babu, Jipnomon Joseph, Uma Devi Padma

DOI: 10.5958/0974-360X.2020.00124.9         Access: Closed Access Read More

Cognitive Enhancement and Neuroprotective Effects of Ancient Ayurvedic Medicinal Plant Celastrus Paniculatus: An Overview

Author(s): Vasudev Pai, C. S Shreedhara, Chandrashekar K. S, Aravinda Pai, Venkatesh Kamath

DOI: 10.5958/0974-360X.2016.00246.8         Access: Open Access Read More

Pharmacognostical and Pharmacological Importance of Cicer arietinum Linn -A Review

Author(s): Karnail Singh, Kavita Gahlot

DOI: 10.5958/0974-360X.2018.00867.3         Access: Open Access Read More

Anti-epileptic Activity of Carica papaya seed extract in Experimental Animals

Author(s): Divya, Prasanna Shama Khandige, Ullas Prakash D’ Souza, Himanshu Joshi, Zeena Fernandes, Gururaj M. P, Nimmy Chackko, Shastry C. S.

DOI: 10.5958/0974-360X.2019.01042.4         Access: Open Access Read More

Acorus calamus linn. : Chemistry and Biology

Author(s): Arasan Elaya Raja, M Vijayalakshmi, Garikapati Devalarao

DOI:         Access: Open Access Read More

Review on Chromen derivatives and their Pharmacological Activities

Author(s): Ravi Kant Kushwaha, Kuldeep Singh, Piyush Kumar, Dinesh Chandra

DOI: 10.5958/0974-360X.2019.00965.X         Access: Open Access Read More

In vitro Anti- Arthritic activity of Sesbania grandiflora Ethyl acetate extract

Author(s): Sripradha, Lakshmi. T

DOI: 10.5958/0974-360X.2015.00269.3         Access: Open Access Read More

Vitex negundo Linn. : Phytoconstituents and Research Findings

Author(s): RV Shete, KV Otari, OG Bichewar

DOI: Not Available         Access: Open Access Read More

Divers Pharmacological Significance of Imidazole Derivatives- A Review

Author(s): Tarani Prakash Shrivastava, Umesh Kumar Patil, Satyendra Garg, Meghna A. Singh

DOI: Not Available         Access: Open Access Read More

Nigella sativa: Phytochemistry, Pharmacology and its Therapeutic Potential

Author(s): Prashant Tiwari, Susmita Jena, Swaroop Satpathy, Pratap Kumar Sahu

DOI: 10.5958/0974-360X.2019.00526.2         Access: Open Access Read More

Anticoagulant activity of Calotropis gigantea leaves

Author(s): Jyoti B. Wadekar, Ramesh L. Sawant, Kunal R. Sanklecha, Amol S. Ghodechor, Priyanka B. Sable, Ganesh D. Barkade

DOI: 10.5958/0974-360X.2016.00290.0         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Synthesis of Novel molecular hybrid 3-(4,5-dihydro-1H-pyrazol-3-yl)-4-hydroxy-2H-chromen-2-one derivatives and In Vitro α-glucosidase and α-amylase inhibitory activity
Hepatoprotective activity of Etlingera elatior (Jack) R.M. Smith Extract against CCl4 -induced Hepatic Toxicity in Male Wistar Rats
Anti-inflammatory activity of Ginger oleoresin mediated Silver nanoparticles
Formulation of Rhizobial Fertilizer for Leguminous Plant Vigna mungo Growth
Quantification Molecular Weight of Human Beta Defensin-2 and Human Beta Defensin-3 from Saliva of Caries patient
Preliminary Phytopharmacological Analysis, Proximate Composition Analysis and Product Development with the Leaves and Fruits of Muntingia calabura L.
UV-Spectroscopic Method development and Validation for simultaneous estimation of Doxylamine succinate and Pyridoxine hydrochloride in bulk and Pharmaceutical dosage form
Impact of Salbutamol in Chronic Obstructive Pulmonary Diseases patients: A prospective observational study on Clinical interventions
Spectrophotometric determination of Sulfasalazine drug in pure and Pharmaceutical preparation using sodium 1, 2-naphthoquinone-4-sulfonate (NQS) reagent
Synthesis and Molecular docking studies of some new Pyrazoline derivatives for Antimicrobial properties
Evaluation of Hepatoprotective activity in methanolic extract of Aerial parts of Hibiscus surattensis
The Study of volume and structure of sales of Pharmaceutical assortment of Antihypertensive drugs to 2019
Selecting a provider as the most important step in building a cold chain in Pharmaceutical Logistics
Formulation Development and Evaluation of Immediate release tablet of Terbinafine Hydrochloride
Evaluation of Metal levels and Physiological parameters in Sickle cell anemia and their comparison with Iron deficiency anemia
HPTLC and Antioxidant activity of Ethanolic Extract of Ipomoea obscura (L.) Ker Gawl Stem
Development, In-Vitro and In-Vivo Evaluation of Gastro Retentive Formulations for Moxifloxacin HCl
Effect of Steam Tomato Extract in Renal and Hepar Rats Loading Alloxan and Fat-Rich Diet
A Study to Identify any relationship between Hand dominance and restrictions in range of Motion in the protracted shoulder
Cytotoxic Potency of Bioactive Metabolites from an Endophytic Fungi Pestaloptiopsis breviseta against MCF-7 and A 549 Cancer cell lines

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 11013
Yesterday: 14881
Total: 3825960