Author(s): Sangeeta S. Tanavade, Smt. Nilofer Naikwade, Dhanyakumar D. Chougule

Email(s): tan.sangeeta@gmail.com

DOI: Not Available

Address: Sangeeta S. Tanavade1*, Dr. Smt. Nilofer Naikwade2, Dhanyakumar D. Chougule3
1Assistant Professor, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli.
2Vice Principal and H.O.D. Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli.
3Principal and H.O.D, Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli.
*Corresponding Author

Published In:   Volume - 5,      Issue - 10,     Year - 2012


ABSTRACT:
In present study in vitro anticancer activity of ethanolic and aqueous extracts of leaves and stems of Peristrophe bivalvis Merrill was evaluated. In vitro anticancer activity was assayed by tryphan blue dye exclusion method and brine shrimp lethality bioassay method. Extracts were found to be cytotoxic in dose dependent manner in both methods. Ethanolic extract was found to be potent than aqueous extract. Leaves showed more significant anticancer activity as compared to stems. The CTC50 of ethanolic extract of leaves was found to be 175.25±12.34 µg/ml in EAC cell lines. The LC50 of ethanolic extract of leaves was176.49±7.43 µg/ml. It indicated that Peristrophe bivalvis Merrill has potential to prevent cancer in a dose dependent manner.


Cite this article:
Sangeeta S. Tanavade, Smt. Nilofer Naikwade, Dhanyakumar D. Chougule. In vitro anticancer activity of Ethanolic and Aqueous Extracts of Peristrophe bivalvis Merrill. Research J. Pharm. and Tech. 5(10): October 2012; Page 1324-1327.


REFERENCES:

1.        American cancer society (2006). A biotechnological company dedicated to cancer treatment.www.cancervax.com/info/index. 

2.        Williams DA., Lemke TL., Foye’s principles of Medicinal Chemistry’ 5th edition, Wolters Kluwer Health (P)Ltd., 2002, pp.462-466,761-782.

3.        The Wealth of India- A dictionary of Indian raw materials and Industrial products, Vol.VII, N-Pe, CSIR, New Delhi,1992, pp.313-314.

4.         http://globinmed.com

5.         http://www.botanyvn.com.

6.        Verma RK., Chourasia L. and Katiyar S., Potential antifungal plants for controlling building fungi, Natural Product Radiance, 7(4), 2008 :374-387.

7.        Kokate CK., Purohit AP., Gokhale SB., ‘Pharmacognosy’, Nirali   Prakashan, 2006, pp. 111-113.

8.        Gothoskar SV., Randive KJ., Anticancer screening of SAN-AB, An extract of marking nut Semicarpus anacardium. Indian  Journal of  Experimental Biology,  9, 1971:372-375. 

9.        Ozaslan M., Karagoz ID., et.al, Ehrlich ascites carcinoma, African Journal of Biotechnology, 10(13), 2011:2375-2378.

10.      Rahman AU., Choudhary MI., and Thomsen WJ., Bioassay Techniques for drug development Taylor and Francis group, New York, 2000, pp. 9 -12:14 -27,28 -39.

11.      Subhadradevi V., Christy J., Asok Kumar K., Umamaheshwari and M., Sivashanmugham AT., Induction of apoptosis and cytotoxic activities of methanolic extract of Careya arborea Roxb bark, Pharmacie Globale (International Journal of Comprehensive Pharmacy), 01( 3) 2010:1 -3.

12.      Gupta M., Mazumdar UK., Haldar PK., et. al, Anticancer activity of Indigofera aspalathoides and Wedelia calendulaceae in swiss albino mice, Iranian Journal of Pharmacy Research, 6(2), 2007:141-145.

13.      Apu AS. Muhit MA. Tareq SM., Pathan AH.et al, Antimicrobial activity and brine shrimp lethality bioassay of the leaves extract of Dillenia indica linn,  Journal of  Young Pharmacy, 2,2008: 50 -54.

14.       Agrawal SS., Saraswati S., Mathur R. Pandey M., Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line. Life Sciences, 2011:1-12.

15.      Ajith TA., Janardhanan KK., Cytotoxic and antitumor activities of a polypore macrofungus, Phellinus rimosus (Berk) pilat, Journal of Ethnopharmacology, 84, 2003 :157-162.

16.       Bala A., Kar B., Haldar PK., Mazumder UK., Bera S., Evaluation of anticancer activity of cleome gynandra on Ehrlich’s Ascites Carcinoma treated mice,  Journal of Ethnopharmacology,129, 2010:131-143.

 

 

 

 

Recomonded Articles:

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Author(s): Arvindganth. R, Anupriya K.V., Kathiravan. G

DOI: 10.5958/0974-360X.2017.00105.6         Access: Open Access Read More

Author(s): V. F. Larichev, I. P. Smirnova, S. P. Syatkin, G. I. Myandina, S. M. Chibisov, Е. А. Ryskina

DOI: 10.5958/0974-360X.2017.00143.3         Access: Open Access Read More

Author(s): Sangeeta S. Tanavade, Smt. Nilofer Naikwade, Dhanyakumar D. Chougule

DOI: Not Available         Access: Open Access Read More

Author(s): S. Krishnakumar, R. Divya, N.R. Kanchana Devi, G. Keerthana, A. Ancy Judi

DOI: 10.5958/0974-360X.2017.00234.7         Access: Open Access Read More

Author(s): Das Biswajit, Dash Suvakanta, Choudhury Ramesh Chandra

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak H B, Sabina Evan Prince

DOI: 10.5958/0974-360X.2017.00491.7         Access: Open Access Read More

Author(s): Nadeem Siddiqui, Waquar Ahsan, M. Shamsher Alam, Andalip, Bishmillah Azad, M. Jawaid Akhtar

DOI: Not Available         Access: Open Access Read More

Author(s): Sahiti K, Raji P, Bennett Rohan, Divya Kumar M, Antony V. Samrot

DOI: 10.5958/0974-360X.2016.00064.0         Access: Open Access Read More

Author(s): Manoj S. Pagare, Hardik Joshi, Leena Patil, Vilasrao J. Kadam

DOI: Not Available         Access: Open Access Read More

Author(s): Sumit Phulera, Neelam Gurung, Kavita Maria Arora, Gaurav Kumar, Loganathan Karthik, Kokati Venkata Bhaskara Rao

DOI: Not Available         Access: Open Access Read More

Author(s): Mukesh Kumar Singh, A. Prathapan, Kushagra Nagori, S. Ishwarya, K.G Raghu

DOI:         Access: Open Access Read More

Author(s): NasimunIslam N1., Jemimah Naine S., Shaik Jameel, S.S. Khora, Venkat Kumar, Mohanasrinivasan V., C. Subathra Devi, Panneerselvam A.

DOI: Not Available         Access: Open Access Read More

Author(s): Shukla Maitri Jayeshkumar, Patel Yashvi, Bhavin Bhimani, Ghanshyam Patel, Jaimin Patel, Upendra Patel

DOI: 10.5958/0974-360X.2019.00157.4         Access: Open Access Read More

Author(s): N. S. Devshetwar1, L.V.G. Nargund1*, Nirmal T. Havannavar2, Shachindra L. Nargund3

DOI: Not Available         Access: Open Access Read More

Author(s): Nitin Kumar, Satyendra Singh, Manvi, Rajiv Gupta

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags