ABSTRACT:
The Schiff base 2-((4-hydroxyphenylimino)methyl)phenol was prepared from salicylaldehyde and 4-Aminophenol by condensation method using standard procedure. Anti-inflammatory and CNS activities of Schiff base were studied using albino rats of both the sexs. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 2-((4-hydroxyphenylimino)methyl)phenol. For the determination of Anti-inflammatory activity, inflammation was induced used 1% Carrageenan suspension. CNS depressant activity of the compound was measured by placing the rat individually in the actophotometer for 10 min. The results obtained showed that the Schiff base was found to exhibit anti-inflammatory, CNS activities. The 2-((4-hydroxyphenylimino)methyl)phenol was found to possessed higher anti-inflammatory activity at third hour than the standard diclofenac with a probability <0.5 and also higher CNS depressant activities than the standard chlorpromazine. The PASS prediction of 2-((4-hydroxyphenylimino)methyl)phenol schiff base indicated that the Laccase inhibitor, 3-Hydroxybenzoate 4-monooxygenase inhibitor, Monophenol monooxygenase inhibitor activities were greater than 80% and can also exhibit other activities like Arylacetonitrilase inhibitor, Taurine dehydrogenase inhibitor activity and Hydroxylamine reductase (NADH) inhibitor activities greater than 70%.