El harti Jaouad1*, Ansar M’hammed1, Lmimouni Badr2, Benomar Ali3, Taoufik Jamal1
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1Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, BP 6203, Rabat Institute, University Mohammed V Souissi, Rabat, Morocco.
2Laboratory of Parasitology-Mycology, Instruction Military Hospital Mohammed V, Rabat, Morocco.
Volume - 5,
Issue - 10,
Year - 2012
The treatment of hydatidosis is primarily surgical but can cause morbidity or mortality, hence the interest in many cases of medical treatment whose main representative is albendazole. The efficacy of this compound against Echinococcus granulosus cysts is proved, but limited by its poor bioavailability. New potential prodrugs were synthesized and their protoscolicidal activity was tested in vitro. Although hydrogen N°1 is important for the albendazole activity, some derivatives have kept an activity relatively important.
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