Author(s): Sandeep Kataria1*, Dilsher Kaur2, Shaival Kamalaksha Rao3, Neha Sharma4, Ravi K Khajuria4

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Address: 1Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajasthan, India. 2Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, Punjab, India 3Department of Pharmacognosy, C.U. Shah College of Pharmacy and Resea

Published In:   Volume - 5,      Issue - 10,     Year - 2012


ABSTRACT:
Objective: To investigate the hepatoprotective and in vivo antioxidant effects of Corchorus depressus in carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Group allotment in this study included vehicle, CCl4, Methanol extract of Corchorus depressus 100, 200, and 400 mg/kg + CCl4 and silymarin 50 mg/kg + CCl4, and treatment was carried out accordingly. On the 7th day, rats were sacrificed and blood was withdrawn by cardiac puncture. The levels and activities of serum biochemical parameters and antioxidant enzymes were then assayed using standard procedures. Results: The results of CCl4-induced liver toxicity experiment showed that rats treated with the methanol extract of Corchorus depressus, and also the standard treatment, silymarin (50mg/kg), showed a significant decrease in ALT, AST, ALP and total bilirubin levels, which were all elevated in the CCl4 group (p < 0.01). The results observed after administration of 200mg/kg methanol extract were comparable to those of silymarin at 50mg/kg (p > 0.05). The methanol extract did not show any mortality at doses upto 5000mg/kg body weight. CCl4 also produced significant (P < 0.05) reductions in the activity of catalase, SOD and GSH, and conversely increased MDA level. Methanol extract of Corchorus depressus produced significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. The standard drug also significantly increased CCl4-diminished antioxidant enzymes activity and reduced CCl4-elevated MDA level. In general, the effects of the standard drug were comparable and not significantly different from those of Corchorus depressus. Conclusion: This study clearly indicates that the methanol extract of Corchorus depressus possesses hepatoprotective and in vivo antioxidant effects. These findings provide scientific support for the traditional use of this herb as an Indian medicine for the treatment of liver diseases.


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