Author(s): Jawed Akhtar, B. Srivastava, Parth Bhatt

Email(s): jawed_pharma@yahoo.com

DOI: Not Available

Address: Jawed Akhtar*, B. Srivastava and Parth Bhatt
School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan.
*Corresponding author

Published In:   Volume - 5,      Issue - 1,     Year - 2012


ABSTRACT:
A selective and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the separation and quantification of telmisartan and indapamide in capsule dosages form has been fist developed and validated. Quantification carried out using Stainless Steel C18 130 x 4.6, 5µm column as a stationary phase and mobile phase comprised of 50mM KH2PO4, Acetonitrile and methanol in proportion of 50:20:30 (v/v/v) with pH adjusted to 3.0 ± 0.1 by using o-phosphoric acid. The flow rate was 1.0 ml/min and monitored at 280 nm. The retention time for telmisartan and indapamide were 11.1 and 4.458 minutes, respectively. The method was validated in terms of linearity, precision, accuracy, ruggedness, and specificity, limit of detection and limit of quantification. The linearity (r2) and percentage recoveries of telmisartan and indapamide were 0.9998 and 99.85 microgram/ml and 0.9988 and 99.91 % respectively. The proposed method is suitable for simultaneous determination of telmisartan and indapamide in capsule dosage form.


Cite this article:
Jawed Akhtar, B. Srivastava, Parth Bhatt. Simultaneous Estimation of Telmisartan and Indapamide in Bulk and Capsule Dosage Form by Reverse Phase High Performance Liquid Chromatography. Research J. Pharm. and Tech. 5(1): Jan. 2012; Page 60-62.


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RNI: CHHENG00387/33/1/2008-TC                     
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