Author(s): Basavaraj M. Dinnimath, Shashank N.S., S.M. Hipparagi, Y. Munishama Gowda

Email(s): basavaraj_dm@yahoo.co.in

DOI: Not Available

Address: Basavaraj M. Dinnimath*1, Shashank N.S.1, S.M. Hipparagi1 and Y. Munishama Gowda2
1Dept. of Pharmaceutical Chemistry, KLEU’S College of Pharmacy, Belgaum, Karnataka
2Kemwell Industries Pvt. Ltd., Bangalore, Karnataka.
*Corresponding Author

Published In:   Volume - 4,      Issue - 9,     Year - 2011


ABSTRACT:
3-chloro-4-fluoro phenyl hydrazine was synthesized from 3-chloro 4-fluoro aniline in the presence of hydrazine hydrate. Compound upon treatment with substituted aromatic aldehydes yielded some Schiff’s bases(2,2’-disubstituted-1(3-chloro-4-fluoro)phenyl hydrazones)which upon treatment with mercapto acetic acid afforded some disubstituted thiazolidin-4-ones. These thiazolidin-4-ones were treated with some substituted aromatic aldehydes to arrive at 5-arylidene derivatives of substituted thiazolidin-4-ones. The compounds were structurally confirmed by IR, 1H NMR and Mass spectral data. The synthesized compounds were screened for their antibacterial, antifungal and antitubercular activities.


Cite this article:
Basavaraj M. Dinnimath, Shashank N.S., S.M. Hipparagi, Y. Munishama Gowda. Microwave Assisted Rapid and Efficient Synthesis and Screening of Halogenated Anilin-yl-Substituted Thiazolidin-4-One Derivatives for Antimicrobial Activities. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1413-1417.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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