Author(s): Gannu Praveen Kumar, Jannu Anand

Email(s): ghalo2010@gmail.com

DOI: Not Available

Address: Gannu Praveen Kumar* and Jannu Anand
Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, Orus, Kareemabad, Warangal, A.P, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 9,     Year - 2011


ABSTRACT:
The popularity and patient compliance of the oral drug delivery route encourages the modern forms of oral dosage forms which are more beneficiary. These include oro-dispersible tablets, controlled release tablets, effervescent and non effervescent gastro retentive floating tablets. Among these, gastro retentive tablets have prominent role in delivery of drugs with constraints such as drugs having absorption window, those absorbed locally from the upper GI tract region, and those with relatively short half-lives. But conventional dosage forms like tablets are losing their integrity due to multiple dosage regimens. Gastro retentive systems overcome these constraints and enable a delivery strategy that will function irrespective of the digestive state, clinical condition, or GI motility of the patient. In addition, longer residence time in the stomach could be advantageous in ensuring local action in the upper part of the small intestine, for example in the treatment of peptic ulcer disease and localized stomach cancers. Furthermore, improved bioavailability is expected for drugs that are absorbed readily upon release in the GI tract, primarily those absorbed from the proximal small bowel. These drugs can be delivered ideally by slow release from the stomach. Various scientific and technological attempts have been made in the development of gastroretentive dosage forms to overcome several physiological adversities, such as short gastric retention time and unpredictable gastric emptying time. Floating microspheres are the gastroretentive dosage forms are able to uniform drug release at a site for an extended period of time. The porosity has an important effect on drug release characteristics and pores may greatly increase the rate of drug expulsion and also floating property. This review highlights the classification, factors, mechanism of floating of microspheres, characterization, preparation method, development, polymers, applications, in-vitro, in vivo drug release studies and the effect of porosity on the drug release.


Cite this article:
Gannu Praveen Kumar, Jannu Anand. Porous floating microspheres: A new dimension in controlled drug delivery. Research J. Pharm. and Tech. 4(9): Sept. 2011; Page 1340-1357.


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5         Access: Open Access Read More

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags