Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Extractive Visible Spectrophotometric Assay for Sumatriptan Succinate Estimation Based on Ion-Association Complex Formation

Author(s): Buridi Kalyana Ramu, K. Raghubabu

Email(s): kalyanaramubrd@gmail.com

DOI: Not Available

Address: Buridi Kalyana Ramu* and K. Raghubabu
Department of Engineering Chemistry, AU College of Engineering, Andhra University Visakhapatnam-530003, AP (India)
*Corresponding Author

Published In:   Volume - 4,      Issue - 8,     Year - 2011

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ABSTRACT:
Two simple and sensitive extractive visible spectrophotometric methods (A and B) for the assay of sumatriptan succinate in pure and dosage forms based on the formation of colored chloroform soluble ion - association associates under specified experimental conditions are described. Two dyes namely acidic dye Naphthalene blue 12 BR (NB12BR, method A) and basic dye methylene blue (MB, method B) are utilized. The extracts of the ion-associates exhibit absorption maxima at 620nm and 650nm for methods A and B respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (4.0 -12) µg/ml for method A, (4.0-20) µg/ml for method B respectively. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the sumatriptan succinate in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.


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Cite this article:
Buridi Kalyana Ramu, K. Raghubabu. Extractive Visible Spectrophotometric Assay for Sumatriptan Succinate Estimation Based on Ion-Association Complex Formation. Research J. Pharm. and Tech. 4(8): Aug. 2011; Page 1212-1215.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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