Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

Email(s): mayanka.s@rediffmail.com

DOI: Not Available

Address: Mayanka Singh*, Manoj Charde, Rajesh Shukla and Rita M. Charde
NRI Institute of Pharmacy, Bhopal
*Corresponding Author

Published In:   Volume - 4,      Issue - 8,     Year - 2011


ABSTRACT:
A simple, specific, sensitive, precise stability-indicating high-performance liquid chromatography method for determination of Calcipotriene was developed and validated. A Zorbax 300 SB-C18 column (250*4.6 mm, 3.5 µ) in isocratic mode, with mobile phase consisting of a mixture of solution methanol: water (70:30) was used. The quantitation performed at flow rate of 1.0 mL/min at 264 nm and run time was 7.5 min. The analytical method was validated as per ICH guideline for linearity, accuracy, precision, specificity, limit of detection, limit of quantification, and stability and method can be extended to the analysis of Calcipotriene in semis olid formulations. The relative standard deviation values for precision was less than 2%, and % recovery was greater than 98% for Calcipotriene. The drug is photo and thermal sensitive, so the analysis should be done in moderate conditions only.


Cite this article:
Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde. Determination of Calcipotriene in Calcipotriene Cream 0.05% w/w by RP-HPLC Method Development and Validation. Research J. Pharm. and Tech. 4(8): August 2011; Page 1219-1223.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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