Author(s): Shaikh Mohammed Vasim, Rahul Thube

Email(s): vasim508@gmail.com

DOI: Not Available

Address: Shaikh Mohammed Vasim* and Rahul Thube
Allana College of Pharmacy, Azam campus, Pune-01.
*Corresponding Author

Published In:   Volume - 4,      Issue - 8,     Year - 2011


ABSTRACT:
Aceclofenac drug is practically water insoluble and it belongs to Biopharmaceutical classification system (class II) and its bioavailability is dissolution dependent. Due to poor aqueous solubility aceclofenac was chosen as a drug candidate to improve its solubility and bioavailability. The method Solid Dispersion (SD) of Aceclofenac was done by Hot Melt technique. In this method the drug and polymer PVP K-30 was heated in a porceline dish at 70ºC to form a molten mass which is kept to dry at room temperature and hence crystals are formed.This method helps to enhance solubility and thus increase bioavailability of the aceclofenac drug. The Solid Dispersion of optimized formulation F4 (aceclofenac: PVP K-30) was prepared by direct compression and were characterized by IR, DSC, FTIR, Stability studies and invitro drug release at pH 7.4. Solid Dispersion tablet showed a percentage drug release of 84% in 50min as compared to that of the 67% in 50 min of the marketed conventional formulation. Dissolution of drug increased by the Solid Dispersion and hence solubility was also increased. It is concluded that solubility of the aceclofenac was improved by Solid Dispersion with PVP K-30.


Cite this article:
Shaikh Mohammed Vasim, Rahul Thube. Solubility Enhancement of Aceclofenac by Hot Melt Solid Dispersion Technique. Research J. Pharm. and Tech. 4(8): August 2011; Page 1307-1310.


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RNI: CHHENG00387/33/1/2008-TC                     
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