Author(s): Chandra Mohan Sahu, D.K. Tiwari, S.J. Ingale, A.K. Singhai

Email(s): cms_23031984@rediffmail.com

DOI: Not Available

Address: Chandra Mohan Sahu*, D.K. Tiwari, S.J. Ingale and A.K. Singhai
1Department of Pharmaceutics, Lakshmi Narain College of Pharmacy, Bhopal (M.P.) India
*Corresponding Author

Published In:   Volume - 4,      Issue - 8,     Year - 2011


ABSTRACT:
The present work is aimed to formulate and evaluate floating tablets of Captopril for its physicochemical properties and in-vitro buoyancy studies using an effervescent approach for gastro retentive drug delivery system. Captopril effervescent floating tablets were developed direct compression technique in nine different formulations (F1 to F9) by employing different grades of polymers HPMC K4M, HPMC K15M and HPMC K100M and effervescent agents such as sodium bicarbonate. Formulation F5 containing HPMC K15M showed good Buoyancy lag time of 120. And it remained float for more than 12 hr in the release medium.


Cite this article:
Chandra Mohan Sahu, D.K. Tiwari, S.J. Ingale, A.K. Singhai. Formulation and Physicochemical Evaluation of Floating Tablets of Captopril. Research J. Pharm. and Tech. 4(8): August 2011; Page 1292-1296.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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