The aim of study was for the development of any formulation, techniques such as thermal and isothermal stress testing were used to assess the compatibility of drug with excipients. Differential scanning calorimetry (DSC) and Fourier transformation infrared spectroscopy (FTIR) were the common methods for the study of compatibility. Isothermal stress testing (IST) is also a method for the compatibility study during proto type formulation. In the present study drug excipients compatibility study of gatifloxacin was conducted with different controlled release excipients. The drug and excipients mixtures were stored at 50°C for 4 weeks. The samples were then characterized using DSC, FTIR and UV spectrophotometric methods. The results show that gatifloxacin was compatible with the all the excipients used in the study. The excipients used in the present study were definitely incorporated in the extended release gatifloxacin formulation.
Cite this article:
Rajendra Jangde, S. J. Daharwal. Compatibility Study of Gatifloxacin with Various excipients. Research J. Pharm. and Tech. 4(8): August 2011; Page 1216-1218.