ABSTRACT:
Gastric hyperacidity and ulcers are common gastrointestinal complications that affect a considerable number of people in the world. A number of excellent drugs, developed over the decades have proven useful in controlling hyperacidity and ulceration but still the problem of relapse has eluded success. Hence an attempt was made to find a therapy with more efficacy and better results. The present study was designed to evaluate the combination effect of selected antioxidants with lansoprazole against aspirin induced gastric ulcer model in rats. The experiment was conducted using 6 groups of albino rats with 6 animals each and the dose calculations were based on body surface area as described by Laurence and Bacharach. The antiulcer effect of the combination of antioxidants with lansoprazole was compared with the reference standard lansoprazole alone. The ulcer index and percentage protection was calculated. All the combination groups showed reduction in ulcer index and the percentage protection was found to be 92.1% for vitamin C + lansoprazole, 89.5% for coenzyme Q10 + lansoprazole, 90.8% for vitamin E + lansoprazole, 88.1% for melatonin + lansoprazole when compared to standard lansoprazole 82.8%. Thus all the combination groups of selected antioxidants with lansoprazole showed significant enhancement of antiulcer activity and were found to be synergistic in nature when compared to standard lansoprazole alone.