Author(s): Nitin M., Girish M., Chetan M., Ather Javed, Krunal S., Krishna Kumar

Email(s): girish.madri24@gmail.com

DOI: Not Available

Address: Nitin M.*, Girish M., Chetan M., Ather Javed, Krunal S. and Krishna Kumar
Department of Pharmacology, HKES College of Pharmacy, Sedam Road, Gulbarga-585105, Karnataka, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 8,     Year - 2011


ABSTRACT:
Gastric hyperacidity and ulcers are common gastrointestinal complications that affect a considerable number of people in the world. A number of excellent drugs, developed over the decades have proven useful in controlling hyperacidity and ulceration but still the problem of relapse has eluded success. Hence an attempt was made to find a therapy with more efficacy and better results. The present study was designed to evaluate the combination effect of selected antioxidants with lansoprazole against aspirin induced gastric ulcer model in rats. The experiment was conducted using 6 groups of albino rats with 6 animals each and the dose calculations were based on body surface area as described by Laurence and Bacharach. The antiulcer effect of the combination of antioxidants with lansoprazole was compared with the reference standard lansoprazole alone. The ulcer index and percentage protection was calculated. All the combination groups showed reduction in ulcer index and the percentage protection was found to be 92.1% for vitamin C + lansoprazole, 89.5% for coenzyme Q10 + lansoprazole, 90.8% for vitamin E + lansoprazole, 88.1% for melatonin + lansoprazole when compared to standard lansoprazole 82.8%. Thus all the combination groups of selected antioxidants with lansoprazole showed significant enhancement of antiulcer activity and were found to be synergistic in nature when compared to standard lansoprazole alone.


Cite this article:
Nitin M., Girish M., Chetan M., Ather Javed, Krunal S., Krishna Kumar. Comparative Influence of Selected Antioxidants with Lansoprazole in Aspirin Induced Ulcer Model in Rats. Research J. Pharm. and Tech. 4(8): August 2011; Page 1273-1277.


Recomonded Articles:

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao U.S., Suganya M. Utharkar, C. Shanmuga Sundaram

DOI: 10.5958/0974-360X.2015.00307.8         Access: Open Access Read More

Author(s): Alai M.S., Shinkar D.M., Saudagar R.B.

DOI: 10.5958/0974-360X.2017.00646.1         Access: Open Access Read More

Author(s): J. Satyanarayana, A. Pavan Kumar, V. Sai Kishore, T.E. Gopala Krishna Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Author(s): Umbare RP, Mate GS, Dongare SS

DOI: Not Available         Access: Open Access Read More

Author(s): Preeti K. Suresh, Abhishek K. Sah, Sanjay J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): Venkateshwarlu Goli, Sravan Prasad Macharla, K. Vijaya Bhasker, N.L Gowrishankar, J. Bhaskar, Ch. Dhanalakshmi

DOI: Not Available         Access: Open Access Read More

Author(s): Lalit Singh, Arun Nanda, Bhupinder Singh, Saurabh Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): M Ali, Ezzat A Genady, Sarfaraz Ahmad, MS Alam, SA Khan, SAH Abdi, MS Harsoliya

DOI: Not Available         Access: Open Access Read More

Author(s): Veeranagoud Biradar, Jeevan Matada Basavarajaiah, Myat Thu Thu Win, Leneena Gudugunta, Suresh KV , Sathiyavathi Mahendra Kumar, Neeraja Turagam, Lavanya Priya

DOI: 10.5958/0974-360X.2019.00622.X         Access: Open Access Read More

Author(s): Jaideep Singh, Shivalinge Gowda KP, Shrishailappa Badami, Rahul Akuskar, Nagarjan Tukuru

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags