Arvind B. Karadi, S. Appal Raju, Shobha Manjunath, Venugopal Darak
Arvind B. Karadi*, S. Appal Raju, Shobha Manjunath and Venugopal Darak
Department of Pharmaceutical Analysis, HKES’s College of pharmacy, Sedam Road, Gulbarga, Karnataka-585105, India.
Volume - 4,
Issue - 8,
Year - 2011
Three simple, sensitive spectrophotometric methods (Method A, B and C) are developed, Method A and B are based on the oxidation followed by complex formation with 1, 10 phenanthroline (Method A) to yield blood red coloured chromogen, 2’2 bipyridine (Method B) to yield red coloured chromogen, Method C based on oxidation of drug with potassium ferricynide to yield blue coloured chromogen, exhibiting absorption maxima at 510, 522 and 716nm , respectively. Beer’s law was obeyed in the concentration ranges of 2-10, 50-150 and 10-60µg/ml respectively. The coloured chromogen was stable for 4hrs. These methods were extended to pharmaceutical formulations and there was no interference from any common excepients which are usually present in tablet dosage formulations. The results of analysis have been validated statistically and by recovery studies.
Cite this article:
Arvind B. Karadi, S. Appal Raju, Shobha Manjunath, Venugopal Darak. Development and Validation of Visible Spectrophotometric Methods for Determination of Cefditoren Pivoxil in Pharmaceutical Formulations. Research J. Pharm. and Tech. 4(8): August 2011; Page 1269-1272.