Beena K.P., Akelesh T.
Beena K.P.1 and Akelesh T.2
1Assistant Professor, Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Coimbatore
2Assistant Professor, Department of Pharmaceutics, R.V.S College of Pharmaceutical Sciences, Coimbatore
Volume - 4,
Issue - 8,
Year - 2011
Pyrimidines occupy a distinct and unique place in our life. This heterocyclic moiety has great biological and medicinal significance. A large array of pyrimidine drugs possess a variety of medicinal properties. A new series of dihydropyrimidines via biginelli reaction were prepared and condensed with hydrazine hydrazine to give carbohydrazido derivatives which was further condensed with phthalic anhydride in presence of ethanol and glacial acetic acid to afford the titled compounds. The infra red spectrum was recorded on a JASCO 4100 FTIR using KBr pellet disc technique. NMR spectra of the synthesized compounds were recorded on a Brucker 300 MHz spectrometer. The spectra were in accordance with the synthesized compounds. All the synthesized compounds were evaluated against Gram-positive bacteriae such as Bacillus lentus, Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and fungi such as Candida albicans and Aspergillus niger to study the effect of introducing phthalic anhydride moiety into pyrimidine nucleus. Most of the novel synthesized compounds had lower antibacterial effects, but significant antifungal activity in comparison with standard drugs. Minimum inhibitory concentration of the titled compounds for fungi was determined by agar dilution method. The highest concentration to inhibit both Aspergillus niger and Candida albicans was found to be 62.5µg/ml.
Cite this article:
Beena K.P., Akelesh T. A Novel Series of Dihydropyrimidines as Possible Antimicrobial Agents. Research J. Pharm. and Tech. 4(8): August 2011; Page 1252-1255.