Author(s): Madgulkar Ashwini R., Sonawane Prajakta A., Dhoka Madhura V., Nimbalkar Umesh A.

Email(s): madhura1777@yahoo.com

DOI: Not Available

Address: Madgulkar Ashwini R., Sonawane Prajakta A., Dhoka Madhura V.* and Nimbalkar Umesh A.
Department of Quality Assurance, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune- 41100, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 7,     Year - 2011


ABSTRACT:
A simple, sensitive high performance thin layer chromatographic method was developed for simultaneous determination of Cefixime Trihydrate and Erdosteine in human plasma. The plasma samples were subjected to the protein precipitation by using acetonitrile. The separation was achieved using dichloromethane: methanol: triethylamine (6.5:3.5:0.07v/v/v) as mobile phase and silica gel Plate 60F254 as stationary phase. Densitometric analysis was carried out at wavelength 235nm. The Rf values for Cefixime Trihydrate and Erdosteine was found to be 0.55±0.03 and 0.75±0.03 respectively. The calibration curves were linear over range of 100-600 ng/spot for Cefixime Trihydrate and 150-750 ng/spot for Erdosteine. The average recovery of Cefixime Trihydrate and Erdosteine was found to be 97.6 % and 97.5 % respectively. Method was found to be reproducible with % coefficient of variance (%CV) for intra and interday precision of not more than 15 for QC samples and not more than 20 for LLOQ over the said concentration range.


Cite this article:
Madgulkar Ashwini R., Sonawane Prajakta A., Dhoka Madhura V., Nimbalkar Umesh A. Simultaneous Determination of Cefixime Trihydrate and Erdosteine in Human Plasma by HPTLC Method. Research J. Pharm. and Tech. 4(7): July 2011; Page 1078-1082.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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