ABSTRACT:
The present work is carried out to study gel formulation in the treatment of periodontal disease. Periodontal diseases are the group of disease occurring in the sulcus-the gap between the gums and tooth. Carbopol can be utilized as an important intra-pocket delivery vehicle for the treatment of the disease because it can easily pass through a cannula into a periodontal pocket where it solidifies in situ to deliver the therapeutic agent for a prolonged period. The use of Carbopol 934 gel base led to improvement in Metronidazole availability at the periodontal pocket. Carbopol gel base containing Metronidazole studied for physicochemical properties like drug release, syringybility, drug content and pH to evaluate the characterization of the gel formulation. From the prepared formulations 0.5% Carbopol gel base showed the highest release of Metronidazole (81.7%) than the 1% Carbopol gel bases (27%) after 120 min. The thixotropic behavior of the gel was expressed by its syringybility. It can be injected directly into the periodontal pocket using a syringe or cannula. The results shown that syringybility and drug release from the medicated gel decrease with the increase in the concentration of Carbopol 934.