Author(s): Anusuya Patil, B.G. Desai, H. N. Shivakumar, Purvang

Email(s): patil_anusuya@yahoo.in , anusuya.raghu@gmail.com

DOI: Not Available

Address: Anusuya Patil*, B.G. Desai, H. N. Shivakumar and Purvang
KLE University’s College of Pharmacy, Bangalore.
*Corresponding Author

Published In:   Volume - 4,      Issue - 7,     Year - 2011


ABSTRACT:
The aim of this study was to investigate the physicochemical properties of Nateglinide in inclusion complex. The phase solubility behavior of Nateglinide in presence of various concentrations of ß-CD in pH 7.4 buffers was obtained at 370C. The solubility of Nateglinide increased with increasing the concentration of ß-CD. The inclusion complex of Nateglinide with ß-CD were prepared at in various ratios (C1-1:1 Nateglinide: ß-CD, C2-1:2 Nateglinide: ß-CD, C3-1:3 Nateglinide: ß-CD) using Kneading method. Prepared inclusion complexes were evaluated by FT-IR, LC-MS, DSC, NMR and SEM. The FT-IR spectroscopic studies showed the stability of Nateglinide and absence of well-defined Nateglinide- ß-CD interaction. Among all prepared inclusion complexes, C3 showed the best release pattern.


Cite this article:
Anusuya Patil, B.G. Desai, H. N. Shivakumar, Purvang. Enhancement of Nateglinide Solubility and Dissolution Rate. Research J. Pharm. and Tech. 4(7): July 2011; Page 1159-1164.


Recomonded Articles:

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Saranya, Parthasarathy V, Hariprasad B, Shobha Rani H

DOI: 10.5958/0974-360X.2016.00233.X         Access: Open Access Read More

Author(s): Ankita Chatterjee, Jayanthi Abraham

DOI: 10.5958/0974-360X.2016.00125.6         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Deependra Jain, Nishiprakash Jain, SK Jain, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Soham Shukla

DOI: Not Available         Access: Open Access Read More

Author(s): Karthikeyan D, Vijayakumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T. Sivakumar T.

DOI:         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Adithya Chandrashekar, Anuraag Muralidharan, Ananthamurthy Koteshwara, Angel Treasa Alex, V. M. Subrahmanyam

DOI: 10.5958/0974-360X.2019.00791.1         Access: Closed Access Read More

Author(s): A. Khuntia, S.K. Mohanty

DOI: Not Available         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags