Author(s): Farheen F., Elango K., Devi Damayanthi R., Santhanalakshmi G.

Email(s): f_fireen@yahoo.co.in

DOI: Not Available

Address: Farheen F.*, Elango K., Devi Damayanthi R. and Santhanalakshmi G.
Department of Pharmaceutics, Madras Medical College, Chennai-03
*Corresponding Author

Published In:   Volume - 4,      Issue - 7,     Year - 2011


ABSTRACT:
The incidence of Inflammatory Bowel Disease (IBD) has risen in recent decades. Prednisolone (PD) is used in moderate to severe conditions. Being a steroid and a very slightly water soluble drug, PD produces toxic side effects. The aim is to optimize and develop a microbially triggered Colon-targeted osmotic pump of PD for treating IBD which also reduces the toxic side effects. Colon-specific biodegradation of Chitosan (CT) is used to deliver PD in the colonic region to reduce its side effects. Matrix tablets of Pectin, Xanthan Gum and Chitosan were prepared using wet granulation method and coated with an inner semi-permeable layer (SP) of ethyl cellulose and CT and an outer enteric layer of Eudragit® L100-55. The tablets were evaluated for their physical properties and their in-vitro release study was performed in simulated gastric fluid (SGF, pH 1.2) for 2 hours, simulated intestinal fluid (SIF, pH 6.8) for 4 hours and simulated colonic fluid (SCF, pH 5) for 18 hours. The results showed that the drug release was negligible in the initial lag period (6 hours) followed by controlled release for up to 18 hours. The release was influenced by the type and amount of the polymer and the percentage of CT in SP. Among the different polymers used, CT was found to be more suitable for colon targeting.


Cite this article:
Farheen F., Elango K., Devi Damayanthi R. , Santhanalakshmi G. Formulation and Evaluation of Controlled Porosity Prednisolone Osmotic tablets for Colon Targeting. Research J. Pharm. and Tech. 4(7): July 2011; Page 1106-1110.


Recomonded Articles:

Author(s): P. Geetha, M. Kousalya, S. Geetha Lakshmi, R. Gopi.

DOI: 10.5958/0974-360X.2016.00046.9         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Sarumathy S., CH Haripriya, Muddala Vara Prasanna Rao, Gayathri K., CH Bala Sudhakar, Divya M., Shanmugasundaram P.

DOI: 10.5958/0974-360X.2015.00272.3         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): M.A. Saleem, Raghavendra V. Kulkurni, Patil Noornadim G

DOI: Not Available         Access: Open Access Read More

Author(s): Saleem M.A., Sudhir S. Pange, Shaikh Ahnaf Umair, Vishal Kumar Singh

DOI: Not Available         Access: Open Access Read More

Author(s): Thulasi V. Menon, C.I. Sajeeth

DOI: Not Available         Access: Open Access Read More

Author(s): S.S. Manikiran, S.N.H. Pratap, N.L. Prasanthi, N. Ramarao

DOI: Not Available         Access: Open Access Read More

Author(s): Akelesh T., Sam Johnson, Udaya Chander J., Subhojit Samantha, Venkatanarayanan R.

DOI: 10.5958/0974-360X.2015.00268.1         Access: Open Access Read More

Author(s): S. Thaminee

DOI: 10.5958/0974-360X.2016.00417.0         Access: Open Access Read More

Author(s): Bhagat B.V., Jagtap A. R., Hapse S. A., Pagar H.J., Wagh A.S., Kale N.R

DOI: Not Available         Access: Open Access Read More

Author(s): G.V. Wadageri, S.A. Raju, S.B. Shirsand, P. Vijay Prakash Reddy

DOI: Not Available         Access: Open Access Read More

Author(s): Nitin Chandrakant Mohire, Adhikrao Vyankatrao Yadav, Vaishali Kondibhau Gaikwad

DOI:         Access: Open Access Read More

Author(s): HK Kunjwani, AM Manikrao ,Rajesh KS, Sable VP, NH Indurwade

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags